Gut Microbiome, Antibiotic Side Effect
Conditions
Keywords
microbiome, intestinal bacteria
Brief summary
The investigators would like to examine the extent of gut microbiome rehabilitation in healthy people after the consumption of antibiotics. Outcomes of probiotic treatment versus bacteriotherapy will be compared.
Detailed description
The investigators would like to examine the extent of rehabilitation of the composition and functioning of the intestinal bacteria in healthy people after the consumption of antibiotics. Since the digestive mocus enables the connection between the host and the bacteria that live within it, the investigators would like to characterize the microbiome in the different areas along the digestive system - before antibiotic treatment and after rehabilitation by probiotic treatment versus bacteriotherapy.
Interventions
DIETARY_SUPPLEMENTProbiotic treatment
4 weeks of probiotic treatment after 7 days of antibiotics (Metronidazole+Ciprofloxacin)
BIOLOGICALBacteriotherapy
Bacteriotherapy (autologous fecal microbiota transplantation) after 7 days of antibiotics (Metronidazole+Ciprofloxacin)
Sponsors
Weizmann Institute of Science
Tel-Aviv Sourasky Medical Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers * Age: 18 years and up * Gender: women and men
Exclusion criteria
* Pregnancy * Age under 18 years * antibiotic treatment 3 months prior to enrollment * Viral Hepatitis * HIV positive
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Microbiome composition | 1 year | stool samples |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Microbiome composition | 1 month | Gastrointestinal tract biopsies |
Countries
Israel
Contacts
Primary ContactNoya Horowitz, PhD
Outcome results
None listed