Influence of Circulating Endothelial Progenitor Cells and Modifiable Vascular Risk Factors on Carotid Plaque Vulnerability

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03218527

Acronym

IMPROVE

Enrollment

120

Registered

2017-07-14

Start date

2015-10-01

Completion date

2018-12-31

Last updated

2017-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerosis, Inflammation, Stroke

Brief summary

Ischemic stroke is a leading cause of death and disability worldwide. Atherosclerosis, responsible for the 20% of ischemic strokes, is characterized by lipid accumulation in the artery wall that leads to chronic inflammation, cell proliferation and ultimately to vessel stenosis. One of the main features related to plaque progression and vulnerability is inflammation. Positron emission tomography with 18-fluorodeoxyglucos (18-FDG PET) allows an accurate quantification of plaque inflammation and it has been proved its usefulness in predicting early stroke recurrences. The investigators aim to test how modifiable vascular risk factors influence plaque inflammation assessed by 18-FDG PET. In addition, investigators will assess the association of this inflammation and circulating endothelial progenitor cells

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Ischemic stroke within 7 days before inclusion * At least one atherosclerotic plaque in the internal carotid artery * \>18 years old

Exclusion criteria

* Cardioembolic strokes according to TOAST criteria * Poor functional outcome (Rankin \>3) after stroke

Design outcomes

Primary

Measure	Time frame	Description
Change in the Standardized Uptake Value (SUV) of the internal carotid artery	Baseline and at one year follow-up	Inflammation change of the internal carotid artery assessed by the Standardized Uptake Value (SUV) obtained with 18FDG-PET scan at one-year follow-up
Change in the Target-to-Background Ratio (TBR) of the internal carotid artery	Baseline and at one year follow-up	Inflammation change of the internal carotid artery assessed by the Target-to-Background Ratio (TBR) obtained with 18FDG-PET scan at one-year follow-up
Change in the Endothelial Progenitor Cells Count	Baseline and at one year follow-up	Change in the Endothelial Progenitor Cells Count by flow cytometry

Countries

Spain

Contacts

Primary ContactPol Camps-Remom, MD

pcamps@santpau.cat+34660030907

Outcome results