Cesarean Scar Pregnancy, Menstruation
Conditions
Keywords
Cesarean Scar Pregnancy
Brief summary
Cesarean scar pregnancy (CSP)is one of the more serious complications of pregnancies that occur after a prior cesarean delivery. No clinical guidelines have been issued for the management of CSP. More than 30 treatment methods are reported to be used in managing CSP. However, which management can achieve better clinical effects remains unknown. Therefore, this prospective study is designed to compare the outcome between MTX + transvaginal surgery and UAE + D&C in the treatment of CSP.
Interventions
PROCEDUREMethotrexate Combined With Transvaginal Surgery
The methods of treatment of CSP
Sponsors
Shanghai First Maternity and Infant Hospital
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
Increased levels of serum β-hCG and ultrasonography findings. The criteria for diagnosis by ultrasonography was the presence of the following: (1) an empty uterine cavity and endocervical canal; (2) detection of the placenta and/or a gestational sac embedded in the hysterectomy scar; (3) the presence of the gestation sac with or without a fetal pole and with or without fetal cardiac activity (depending on the gestational age) in the anterior part of the uterine isthmus; and (4) a thin (1-3 mm) or absent myometrial layer between the gestational sac and the bladder. All patients had taken Magnetic Resonance Imaging (MRI) to clarify the diagnosis . Pregnancy tissues were identified by histopathology examinations of the surgical tissues.
Exclusion criteria
All enrolled patients had no contraindications for transvaginal surgery or UAE, including renal failure, active pelvic infection, clotting disorders, or known allergy to the contrast material.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Duration of menstruation by questionnaire | six months after treatment | Duration of menstruation |
| Endocrine level by blood examination | six months after treatment | FSH in IU/L |
| Volume of menstruation by questionnaire | six months after treatment | in pictorial blood loss score |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The length of the CSD by MRI | six months after treatment | millimeter |
| The depth of the CSD by MRI | six months after treatment | millimeter |
Countries
China
Contacts
Primary ContactXipeng Wang
Backup ContactHuihui Chen
Outcome results
None listed