The Association Between Preoperative CPEX and Postoperative Morbidity Following Oesophagectomy

The Association Between Preoperative Cardiopulmonary Exercise Test Variables and Short-term Postoperative Morbidity Following Oesophagectomy: a Hospital-based Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03216694

Enrollment

254

Registered

2017-07-13

Start date

2017-07-21

Completion date

2018-03-01

Last updated

2019-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oesophageal Cancer

Brief summary

A retrospective hospital-based cohort study of the association between preoperative cardiopulmonary exercise test (CPEX) variables and short-term postoperative morbidity following oesophagectomy.

Detailed description

The aim of this study is to examine the correlations between preoperative CPEX variables (VO2max and Anaerobic Threshold) and 30 day postoperative all cause morbidity in a sample large enough to allow (should significant associations exist) calculation of a threshold value. Secondary aims are to examine associations between the VO2max, AT and cardiopulmonary, non-cardiopulmonary complications as well as specific complications (atrial fibrillation, pneumonia, and anastomotic leak) as well as 30 and 90 day mortality.

Interventions

DIAGNOSTIC_TESTCardiopulmonary exercise testing

Aerobic fitness measured using a cycle ergometer and metabolic cart

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

i. male and female ii. underwent an oesophagectomy iii. completed a pre-operative CPEX test

Exclusion criteria

i. patients that were unable to complete a full CPEX test ii. emergency or palliative surgery iii. pharyngolaryngo-oesophagectomy iv. oesophagectomy and gastrectomy

Design outcomes

Primary

Measure	Time frame	Description
All cause postoperative morbidity	30 days	Classified using Esophageal Complications Consensus Group (ECCG) definitions \[1\] and graded using Clavien-Dindo severity classification \[2\].

Secondary

Measure	Time frame	Description
Non-cardiopulmonary complications	30 days	Classified using ECCG definitions and graded using Clavien-Dindo severity classification.
Mortality	30 days	All cause mortality.
Cardiopulmonary complications	30 days	Classified using ECCG definitions and graded using Clavien-Dindo severity classification.
Atrial fibrillation	30 days	Classified using ECCG definitions and graded using Clavien-Dindo severity classification.
Anastomotic leak	30 days	Classified using ECCG definitions and graded using Clavien-Dindo severity classification.
Pneumonia	30 days	Classified using ECCG definitions and graded using Clavien-Dindo severity classification.

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026