SIBO & SIFO After Colectomy

Does Colectomy Predispose to Small Intestinal Bacterial (SIBO) and Fungal Overgrowth (SIFO)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03216239

Enrollment

100

Registered

2017-07-13

Start date

2015-02-24

Completion date

2016-02-26

Last updated

2018-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colectomy, Small Intestinal Bacterial Overgrowth, Small Intestinal Fungal Overgrowth

Brief summary

After subtotal colectomy, 40% of patients report abdominal pain, gas and diarrhea, and poor quality of life; whose etiology is unknown. The investigators determined whether small intestinal bacterial (SIBO or fungal overgrowth SIFO) could cause these sympotoms (\> 1 year).

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

patients who were referred to a specialist motility center over 4 year period with: * Unexplained gastrointestinal symptoms such as gas, bloating, belching, diarrhea, and abdominal discomfort * history of colectomy * patients with no history of colectomy * patients included who had normal: upper endoscopy, colonoscopy, computerized abdominal tomography scan, and normal hematology, biochemical profiles, tissue transglutaminase antibody, thyroid stimulating hormone, and normal right upper quadrant ultrasound scan. * patients with glucose breath test and/or duodenal aspirate

Exclusion criteria

* patients with upper gut or small bowel surgery * Patients who were hospitalized or with serious cardiac or pulmonary or neurologic comorbidities * Patients with intestinal strictures or known intestinal motility disorders such as scleroderma or pseudo-obstruction syndrome

Design outcomes

Primary

Measure	Time frame	Description
Prevalence of SIBO/SIFO	4-5 years	Patients with unexplained GI symptoms following colectomy and to compare this with a control group of patients with similar symptoms but without previous colectomy.

Secondary

Measure	Time frame	Description
Response to treatment with antibiotics and antifungals	4-5 years	Secondary aim was to assess the response to treatment with antibiotics and antifungals in colectomy patiens with SIBO/SIFO

Outcome results