Climat Impact on Urinary Iodine Concentration

Assessment of Impact of High Temperature Climate on Urinary Iodine Concentration in Women of Reproductive Age

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03215680

Acronym

LION

Enrollment

363

Registered

2017-07-12

Start date

2017-07-10

Completion date

2018-12-31

Last updated

2021-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Iodine Deficiency

Keywords

Urinary iodine concentration

Brief summary

Urinary iodine concentration (UIC) is the recommended biomarker of iodine status in populations. Yet, the influence of climate on UIC remains unclear. Hot climate may reduce urine volume and consequently increase UIC independent of iodine status. This could lead to an overestimation of population iodine intake, thus masking iodine deficiency in vulnerable groups. In this longitudinal observational cohort study in women of reproductive age we will collect 24h and spot urine samples in the summer and winter season. The influence of high temperature climates on UIC, measured and estimated urinary iodine excretion will be estimated.

Interventions

OTHERClimate

Hot and temperate climate

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 49 Years

Healthy volunteers

Yes

Inclusion criteria

* Female * Non-pregnant and non-lactating * General good health, assessed by no reported treatment for chronic disease * Non-smoking * No known history of major medical illnesses or thyroid dysfunction as well as gastrointestinal or metabolic disorders and taking no chronic medication * Residence at the respective study site for 12 months or longer and no plans of moving away during the study year. * No use of iodine containing dietary supplements during the last 6 months * No use of X-ray / CT contrast agent or iodine containing medication within the last year * No use of iodine containing disinfectants during the last 6 months * Participants should be between 18 and 49 years at date of enrollment

Design outcomes

Primary

Measure	Time frame	Description
Urinary iodine concentration	6 months	Measured in 24h urine collections

Secondary

Measure	Time frame	Description
Urinary iodine excretion	6 months	Measured in 24 h urine collections

Other

Measure	Time frame	Description
Urinary iodine concentration	6 months	Measured in spot urine samples
Urinary iodine excretion	6 months	Measured in spot urine samples

Countries

South Africa, Tanzania

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 20, 2026