Endolymphatic Hydrops
Conditions
Brief summary
The aim of this study is to compare 3 methods for the diagnosis of endolymphatic hydrops (EH) in patients with Meniere's disease: MRI 3 Tesla (to visualise EH directly), and functional explorations, namely electrocochleography and dephasing of acoustic distortion products (which are modified by the EH). The research hypothesis is that the examinations will show agreement in the diagnosis of EH, and that the results obtained (quantitative values) will vary in the same direction over time and during flares of MD.
Interventions
DIAGNOSTIC_TESTMRI 3T
Sponsors
Centre Hospitalier Universitaire Dijon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* persons who have provided written consent * persons aged 18 to 75 years * persons with certain, probable or possible Meniere's disease according to the international classification AAO-HNS
Exclusion criteria
* persons without health insurance cover * adults under guardianship * persons with a history of hypersensitivity to the active substance or to one of the excipients of the contrast agent used for the MRI or to any gadolinium chelate * pregnant or breast-feeding women * severe acute or chronic kidney failure * other identified causes of cochleo-vestibular syndromes * Impossibility to follow-up or carry out any of the examinations necessary for the protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of patients for whom an endolymphatic hydrops was diagnosed by electrocochleography | day one |
| Number of patients for whom an endolymphatic hydrops was diagnosed by (Dephasing) of acoustic distortion products | day one |
| Number of patients for whom an endolymphatic hydrops was diagnosed by 3T MRI 3T | day one |
Countries
France
Outcome results
None listed