Trans-parenchymal Compressing Suture in Major Liver Resection

Application of Trans-parenchymal Compressing Suture in Major Liver Resection to Decrease Cutting Surface Related Complication.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03215290

Enrollment

382

Registered

2017-07-12

Start date

2016-10-31

Completion date

2017-02-28

Last updated

2017-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Carcinoma Resectable

Brief summary

Non-anatomical liver resection with appropriate resection margin was regarded as a potential curative treatment for selected major hepatic carcinoma due to preserving maximal normal liver, especially in cirrhotic patients. But occurrence of cutting surface related complications become a main challenge.

Detailed description

In order to better manage the cutting surface after liver resection, we further applied trans-parenchymal compressing suture to not good cutting surface in hope of decreasing cutting surface related complication. A majority of studies investigating cutting surface management are limited to non-surgical treatments, such as the application of hemostasis agents including fibrin sealants, oxidized cellulose, and absorbable gelatin sponge13-15 . But there is no consensus regarding the necessity of the hemostatic agent application to the liver cutting surface. Up to date, few studies investigate surgical suture management of the cutting surface in liver resection.

Interventions

PROCEDURETCS

The cutting surface recognized as not good cutting surface was further trans-parenchymal compressing sutured, if possible, using a hepatic needle.

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

1. tumor size more than 5cm 2. non-anatomical liver resection;

Exclusion criteria

1. intravascular infiltration with tumor embolus; 2. previous liver surgical treatment (e.g. microwave ablation; preoperative transcatheter arterial chemoembolization (TACE); 3. other concomitant extrahepatic procedures (e.g. splenectomy). 4. exposed Glisson Shealth, main hepatic veins or (and) retro-hepatic inferior vena cava.

Design outcomes

Primary

Measure	Time frame	Description
Cutting surface related complications	90 days	After liver resection, some complication related cutting surface may occur, including surgery site infection, bile leakage, bleeding.

Secondary

Measure	Time frame	Description
Interventions for cutting surface related complications	90 days	Once the cutting surface related complications occur, some interventions need to be performed to treat these complications, such as percutaneous abdominal paracentesis or reoperation.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026