Prostate Cancer
Conditions
Brief summary
We aim to evaluate the change in optic nerve sheath diameters as a surrogate of intracranial pressure before and after mannitol administration in patients who undergo robot assisted laparoscopic radical prostatectomy with pneumoperitoneum and Trendelenburg position.
Detailed description
Mannitol has been frequently used for renal protection during surgery. Optic nerve sheath diameter is used to evaluate intracranial pressure noninvasively. Robot-assisted laparoscopic radical prostatectomy can induce an increase in optic nerve sheath diameter due to Trendelenburg position and carbon dioxide insufflation. We therefore aim to evaluate the change in optic nerve sheath diameters before and after mannitol administration in patients who undergo robot assisted laparoscopic radical prostatectomy.
Interventions
DRUGMannitol
The mannitol has been administered routinely to prevent renal dysfunction in patients undergoing robot-assisted laparoscopic radical prostatectomy. Participants will receive the mannitol as part of routine medical care, and we will evaluate the change in optic nerve sheath diameters before and after mannitol administration.
Sponsors
Asan Medical Center
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
20 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* prostate cancer patients undergoing robot assisted laparoscopic radical prostatectomy. * 20 year old or above, 79 year old or below. * agreed to participate this study.
Exclusion criteria
* history of cerebrovascular accident. * history of congestive heart failure. * history of pulmonary edema. * history of anaphylaxis to mannitol. * conversion to open prostatectomy. * combined with other operation. * inability to measure optic nerve sheath diameter.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in optic nerve sheath diameters | 5 minutes after pneumoperitoneum and Trendelenburg position, 90 minutes after mannitol administration during pneumoperitoneum and Trendelenburg position | Change in optic nerve sheath diameters before and after mannitol administration |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in optic nerve sheath diameters | 5 minutes after pneumoperitoneum and Trendelenburg position, 60 minutes after mannitol administration during pneumoperitoneum and Trendelenburg position | Change in optic nerve sheath diameters before and after mannitol administration |
| Optic nerve sheath diameter | 10 minutes after induction of anesthesia | Optic nerve sheath diameter before mannitol administration |
Countries
South Korea
Outcome results
None listed