Effects of Phytonutrients Upon Muscle Perfusion in Response to Feeding

A Pilot Study to Explore the Acute Effects of Phytonutrients Upon Muscle Microvascular Blood Flow (Perfusion) in Response to Feeding in Older Adults.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03213340

Enrollment

Registered

2017-07-11

Start date

2017-09-14

Completion date

2019-10-02

Last updated

2020-01-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Biological Aging

Brief summary

This is a random order cross over design trial to evaluate the efficacy of select nutritional ingredients on enhancing muscle perfusion in response to an acute meal stimulus.

Interventions

OTHERCatechin Cohort 1

\- 4 capsules taken with water 1 hour prior to meal

OTHERCurcuminoid Cohort 2

\- 2 capsules taken with water 1 hour prior to meal

OTHERFlavonoid Cohort 3

\- \ 1 oz. serving consumed 30 minutes before meal

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

OTHER

Masking

SINGLE (Subject)

Intervention model description

3 cohorts, crossover within cohort

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Body mass index (BMI) 18-30 kg/m2 * Free from active metabolic disease * Normotensive

Exclusion criteria

* Habitual gym use or formal exercise (more than once a week) or other routine strenuous physical activity * Smokers * Surgery within past 3 months * Active cardiovascular disease * Taking beta-adrenergic blocking agents * Cerebrovascular disease: * Active respiratory disease * Active metabolic disease * Active inflammatory bowel or renal disease * Active Malignancy or until confirmed remission * Clotting dysfunction * History of DVT * Significant musculoskeletal or neurological disorders * Family history of early (\<55y) death from cardiovascular disease * Known sensitivity to Sonovue contrast agent * Known allergy or intolerance to any of the study ingredients * Current use of any of the study ingredients

Design outcomes

Primary

Measure	Time frame	Description
muscle microvascular blood flow	Baseline to 240 minutes	contrast enhanced ultrasound

Secondary

Measure	Time frame	Description
muscle macrovascular blood flow	Baseline to 240 minutes	doppler ultrasound
central vascular blood flow	Baseline to 90 minutes	echocardiography
cerebral blood flow	Baseline to 120 minutes	doppler ultrasound
endothelial function	Baseline to 120 minutes	flow mediated dilation

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026