Blood Ammonia as Predictor for Esophageal Varices and Risk of Bleeding

Evaluation of Blood Ammonia Level as a Non Invasive Predictor for Presence of Gastroesophageal Varices and Risk of Bleeding

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03212872

Acronym

Enrollment

150

Registered

2017-07-11

Start date

2016-07-07

Completion date

2018-12-31

Last updated

2017-07-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Liver Disease, Esophageal Varices

Keywords

Ammonia, bleeding risk factors, endoscopic risk signs for bleeding, esophageal varices

Brief summary

Assessment of blood ammonia level as a non-invasive predictor for presence of EV and risk of bleeding

Detailed description

A prospective cross sectional study on 150 consecutive patients screening for esophageal varices. Patient groups groups: Group (1): 100 patients with esophageal varices Group (2): 50 chronic liver disease patients with no esophageal varices as a control group. All patients will be subjected to: 1. \- Detailed history-taking 2. \- Full clinical examination 3. \- Laboratory investigations: * Complete blood picture (CBC) * Erythrocyte sedimentation rate (ESR) * Renal function tests * Liver function tests * Prothrombin time and activity * Viral markers (HCV Ab - HBV Ag) * Blood ammonia level. 4. \- Pelviabdominal US: Ultrasound examination of the liver, portal venous system, spleen, kidney and other abdominal organs. 5. \- Upper GITendoscopy: * Varices will be classified according to the Japanese classification 1996, * The Baveno 11 score will be used to differentiate between mild and severe portal hypertensive gastropathy.

Interventions

DIAGNOSTIC_TESTEndoscopy

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

SCREENING

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients with chronic liver disease

Exclusion criteria

* Patient in hepatic encephalopathy or coma. * Patient in active bleeding or with history of bleeding within the two weeks prior to entry in the study . * Patients with heart failure. * Patients with renal failure. * Patient with hepatocellular carcinoma and portal vein thrombosis. * Patient taking Beta blockers.

Design outcomes

Primary

Measure	Time frame	Description
level of serum ammonia in patients with risk factors for bleeding from esophageal varices	24 months	estimation of level of serum ammonia in patients with risk factors for bleeding from esophageal varices

Countries

Egypt

Contacts

Primary ContactFerial El-Kalla, MD

f.elkalla@gmail.com00201006023289

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026