Hematologic Malignancies
Conditions
Keywords
Exercise capacity, Physical activity, Quality of life, Pulmonary functions, Muscle strength, Respiratory muscle strength, Respiratory muscle endurance, Dyspnea, Anxiety, Fatigue
Brief summary
Hematologic malignancies are neoplasms that affect the blood, bone marrow, and lymph nodes. Hematological malignancies are the most common forms of leukemia, lymphoma, and myeloma, with numerous subtypes. The general symptoms of leukemia are fatigue, increased susceptibility to infection, bleeding, and the formation of bruises easily. Typical lymphoma symptoms are night sweats and involuntary weight loss, recurrent fever, fatigue, and itching. Myeloma patients often have bone pain, fatigue, anemia, hypercalcemia or infection symptoms. Adverse effects of hematologic malignancies and treatments cause abnormality in physical function and quality of life. Treatments such as chemotherapy, radiotherapy and hematopoietic stem cell transplantation, which may have side effects on the body systems are used in early or late period. The most common side effect due to chemotherapy is fatigue. Vomiting, weight loss, anemia, depression, decreased aerobic capacity, loss of muscle strength, decreased physical functioning and deterioration in the quality of life are indirect side effects seen in patients. In the literature, side effects of hematological malignancies have been investigated after treatment in patients. However, no study investigated exercise capacity, quality of life, physical activity level and pulmonary functions on newly diagnosed hematologic malignant patients. Therefore, the investigators aimed to compare aforementioned outcomes in newly diagnosed hematologic malignant patients and healthy controls.
Detailed description
According to sample size calculation 30 newly diagnosed hematologic malignant patients and 30 healthy individuals will be included. Before treatment submaximal exercise capacity, physical activity, quality of life, pulmonary functions, respiratory and peripheral muscle strength, respiratory muscle endurance, dyspnea and fatigue perception, anxiety and depression will be evaluated. Primary outcome measurements are exercise capacity, physical activity, quality of life, secondary outcomes are respiratory and peripheral muscle strength, respiratory muscle endurance, pulmonary functions, dyspnea and fatigue perception, anxiety and depression.
Interventions
None listed
Sponsors
Gazi University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Newly diagnosed hematological malignant patients * 18-65 years of age * under standard medications.
Exclusion criteria
* having cognitive disorder, * orthopedic or neurological disease with a potential to affect functional capacity, * comorbidities such as asthma, chronic obstructive pulmonary disease (COPD), acute infections or pneumonia, * problems which may prevent evaluating such as visual problems and mucositis * having metastasis to any region (bone etc.) * having acute hemorrhage in the intracranial and / or lung and other areas * having any contraindication to exercise training
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Functional exercise capacity | first day | Evaluated using 6-minute walking test |
| Physical activity | first day | Evaluated using a metabolic holter |
| General quality of life | second day | Evaluated using QOL using European Organization for Research and Treatment of Cancer QOL Questionnaire (EORTCQOL) |
| Disease-specific quality of life | second day | The Functional Assessment of Cancer Therapy-Leukemia (FACT-Leu) |
| FACT | second day | The Functional Assessment of Cancer Therapy-Anemia (FACT-An) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Dyspnea | first day | Evaluated using Modified Medical Research Council Dyspnea scale (MMRC) |
| Activity dyspnea | first day | Evaluated using Modified Borg Scale |
| Pulmonary functions | first day | Evaluated using spirometer |
| Depression | second day | Montgomery-Åsberg Depression Rating Scale |
| Hospital depression | second day | Evaluated using Hospital Anxiety and Depression Scale |
| Anxiety | second day | Evaluated using Hospital Anxiety and Depression Scale |
| Muscle strength | second day | Evaluated using hand-held dynamometer for peripheral muscles (shoulder abduction, shoulder flexion, knee extension, hand grip strength) |
| Respiratory muscle strength | second day | Evaluated using mouth pressure device |
| Respiratory muscle endurance | second day | Evaluated using respiratory muscle trainer (POWERbreathe) |
| Fatigue | second day | Evaluated using Fatigue Severity Scale |
Countries
Turkey (Türkiye)
Outcome results
None listed