Brain Injuries, Mechanical Ventilation
Conditions
Keywords
brain-injured patients, patient-ventilator asychrony
Brief summary
Mechanical ventilation is an important support strategy for critically ill patients. It could improve gas exchange, reduce the work of breathing, and improve patient comfort. However, patient-ventilator asynchrony, which defined as a mismatch between the patient and ventilator may obfuscate these goals. Studies have shown that a high incidence of asynchrony (asynchrony index \> 10%) is associated with prolonged mechanical ventilation and ICU length of stay and high mortality. So far, there have been only a few studies on the epidemiology of asynchrony in brain-injured patients. Investigators conduct a prospective observational study among brain-injured patients to determine the prevalence, risk factors and outcomes of patient-ventilator asynchrony. Esophageal pressure monitoring, a surrogate for pleural pressure, combined with airway pressure and flow waveforms is used to detect patient-ventilator asynchrony.
Interventions
None listed
Sponsors
Jian-Xin Zhou
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 1\) \]older than 18 years 2) with brain injury in the ICU 3) mechanical ventilated for at least 72 hours
Exclusion criteria
* 1\) ICU length of stay less than 24 hours 2) enrolled in another trial
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of patient-ventilator asynchrony in brain-injured patients | Three days | The incidence of different types of patient-ventilator asynchrony in brain-injured patients. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The risk factors of patient-ventilator asynchrony in brain-injured patients | Three days | The risk factors of different types of patient-ventilator asynchrony in brain-injured patients |
Countries
China
Outcome results
None listed