Thrombocythemia Essential
Conditions
Keywords
Essential thrombocythemia, Multiplate, ROTEM, haemorrhage, thrombosis, Vasodilatator Stimulated Phosphoprotein (VASP)
Brief summary
There is no prospective study published on the Essential Thrombocythemia and the correlation between this specific disease, its complications and the biological variations observed. The aim of this study is to demonstrate a correlation between biological tests of haemostasis, as Multiplate analyser and thromboelastometry (ROTEM) and the occurrence of clinical complications, thrombosis and/or haemorrhage, in order to determine if this biological tests could be biological prognostic factors
Interventions
BIOLOGICALbiological tests of haemostasis at each consultation (Multiplate, ROTEM, VASP)
Patients will have blood samples at each consultation (2 or 3 sampling tubes) in order to carry out systematically three biological tests
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult aged more than 18 years old * Patient followed in consultation for an Essential Thrombocythemia at diagnosis or during the follow-up * Collection of the informed consent * Patient affiliated to Social Security
Exclusion criteria
* Patients aged less than 18 years old * Refusal of signature of the informed consent * Patients under guardianship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Occurrence of thrombotic complications | every 4 months, up to 18 months | All thrombotic complications will be gathered by the investigators during the four months following the realization of Multiplate and ROTEM test |
| Occurrence of haemorrhagic complications | every 4 months, up to 18 months | All haemorrhagic complications will be gathered by the investigators during the four months following the realization of Multiplate and ROTEM test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Occurrence of thrombotic complications | every 4 months, up to 18 months | All thrombotic complications will be gathered by the investigators during the four months following the realization of VASP test |
| Occurrence of haemorrhagic complications | every 4 months, up to 18 months | All haemorrhagic complications will be gathered by the investigators during the four months following the realization of VASP test |
| Changes of tests results according to medical treatments | every 4 months, up to 18 months | All modifications of medical treatments will be gathered at each consultation to analyse changes of biological tests results |
| Description of platelet physiopathology | the day of inclusion | Using a specific test of release of ATP to study the platelet physiopathology in Essential Thrombocythemia only for patients seen at diagnosis and naive of all medical treatment |
Countries
France
Outcome results
None listed