Skip to content

Pulmonary Evaluation With Ultrasound in Different Levels of PEEP

Pulmonary Evaluation at Different Levels of PEEP: Ultrasonography Compared to Electrical Impedance Tomography (TIE) During Intraoperative Elective Surgeries

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03211936
Acronym
EVALUS
Enrollment
40
Registered
2017-07-11
Start date
2015-12-15
Completion date
2017-04-15
Last updated
2017-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atelectasis, Hypertension, Lung Edema

Brief summary

Patients submitted to general anesthesia and artificial ventilation almost always develop pulmonary atelectasis, which can determine adverse consequences both intraoperatively and postoperatively. It is recommended to use physiological tidal volume (6 - 8 mL / kg of ideal body weight) during the intraoperative period in order to minimize the risk of lung injury. To prevent the formation of atelectasis, minimizing the risk of complications, the use of PEEP has been recommended. At present, there is no way to make an optimal adjustment of PEEP to the needs of each patient, seeking a value that keeps the alveoli open without forming atelectasis and also without areas of hyperdistension. The aim of this study was to evaluate the agreement between the ultrasound and the electrical impedance tomography - Timpel® (TIE) to detect the beginning of the formation of areas of atelectasis after pulmonary recruitment, with decreasing PEEP values. In addition, the lung ultrasound will be validated for intraoperative use for both adequacy of PEEP, as well as quantitative analyzes of ultrasound images to assess atelectasis. 18 patients (\> 18 years) of both sexes, submitted to general anesthesia, will be prospectively studied. All patients will receive, in addition to the usual monitoring, the monitoring with the electrical impedance tomography and chest ultrasonography, after being anesthetized and under neuromuscular block, being ventilated with an inspired fraction of 50% oxygen (or greater to maintain oxygen saturation \> 96% ), Tidal volume of 6 mL / kg and respiratory rate to maintain expiratory tidal CO2 between 35-45 cmH2O.

Interventions

PROCEDUREPEEP TITRATED

After titrated peep levels, we choice this level of peep for de group (peep titrated)

DEVICEUse ultrasound

We make a lung ultrasound after we setup a different level of PEEP

DEVICEImpedance tomography

We use the impedance tomography to titrate peep levels, and acquire dates of collapse, hyperdistension and compliance.

OTHERBest PEEP for less collapse

After titrated PEEP levels we setup the best PEEP the according of tomography impedance

OTHERPEEP 4

We set the peep level after titrated peep = 4 cmH20.

Sponsors

Instituto do Cancer do Estado de São Paulo
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender
ALL
Age
30 Years to 60 Years
Healthy volunteers
Yes

Inclusion criteria

* Participants will be male and female patients, over 18 years of age, who undergo abdominal surgeries (prostatectomies and hysterectomies) and who do not have preexisting pulmonary diseases. They will be approached in the room prior to surgery, at which time the purpose of the research will be explained, besides making clear that it will not entail costs and so little any injury, scar, or damage. If accepted by the patient, the consent form will be applied.

Exclusion criteria

*

Design outcomes

Primary

MeasureTime frameDescription
Hyperdistensionduring tritiate peepWe acquire lung ultrasound images during tritiating peep and analyze if any patient have hyperdistension

Secondary

MeasureTime frameDescription
Atelectasisin the final of the procedureAfter the procedure we analyze with patient group have more atelectasis

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026