Idiopathic Pulmonary Fibrosis Job Exposures Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03211507

Acronym

IPFJES

Enrollment

960

Registered

2017-07-07

Start date

2017-05-01

Completion date

2019-10-05

Last updated

2019-12-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Idiopathic Pulmonary Fibrosis, IPF

Keywords

Idiopathic Pulmonary Fibrosis

Brief summary

A case-control study to investigate whether job exposures are an under-recognized cause of idiopathic pulmonary fibrosis (IPF) using an interview to collect information about previous jobs and a blood test to investigate genetic susceptibility.

Detailed description

Idiopathic pulmonary fibrosis (IPF) is a scarring lung disease. It damages the air sacs that allow oxygen to be transferred into the blood and transported to vital organs. These changes make people with IPF cough and feel short of breath. It not known what causes the damage. People who get IPF are usually older than 40; it's a very serious illness that cannot be cured and gets worse over time. Statistics show that IPF is becoming more common in the UK but it's not known why. It can be difficult for doctors to tell if someone has IPF or another disease called asbestosis.

Interventions

OTHERComputer-assisted telephone interview

Occupational history

GENETICGenetic analysis

To include analysis of known susceptibility markers

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Healthy volunteers

Inclusion criteria

For cases Inclusion Criteria: * New diagnosis of IPF between February 2017 and October 2019

Exclusion criteria

* Unable to give informed consent * Ever worked outside of the UK For controls Inclusion Criteria: * New outpatient department attendee between February 2017 and October 2019

Design outcomes

Primary

Measure	Time frame	Description
Association between asbestos exposure and IPF	2 years	estimated using logistic regression for any vs no asbestos exposure and adjusting for age and smoking status

Secondary

Measure	Time frame	Description
Dose-response relationship between asbestos exposure and IPF	2 years	estimated using logistic regression for categories of cumulative exposure and adjusting for age and smoking status
Gene-environment interaction (for MUC5B rs35705950 and asbestos exposure) odds ratio.	2 years	MUC5B rs35705950 and asbestos exposure odds ratio.

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 10, 2026