Obstetric Labor, Premature
Conditions
Brief summary
The aim of this study is to investigate the In Vitro and In Vivo effect of progesterone on immature myeloid cells (IMC), inflammation characteristics and maturation into dendritic cells (DC).
Interventions
BIOLOGICALCulture with progesterone
Progesterone, a steroid hormone will be cultured with placental IMC cells or peripheral blood CD14+ monocyte cells
BIOLOGICALCulture without progesterone
Culture of placental IMC cells or peripheral blood CD14+ monocyte cells without progesterone
BIOLOGICALCulture with growth factors
Culture of placental IMC cells with growth hormones only and analysis
Sponsors
Hillel Yaffe Medical Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Placentas from term and preterm deliveries * Singleton pregnancy * Consent to participate
Exclusion criteria
* Pregnancies with obstetric complications * Multiple gestation * Maternal illness or fetal malformation known pre-delivery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Inflammation characteristic effects of progesterone on preterm and term placentas | One year | Differences observed in cytokine profiles of IMC cells from term and preterm placentas cultured with and without progesterone |
| Maturation effects of progesterone on preterm and term placentas | One year | Differences observed in maturation of IMC cells into DC cells in term and preterm placentas |
Countries
Israel
Outcome results
None listed