Knee Osteoarthritis
Conditions
Keywords
Knee joint, Cartilage degeneration, Ultrasound imaging, Full-Field Optical Coherence Tomography, 9,4 Tesla MRI, Multimodal evaluation
Brief summary
Evaluation and comparison of histological analysis, 9,4 tesla MRI, Full-Field Optical Coherence Tomography (FFOCT) and ultrasound-based navigation system for cartilage degeneration analysis of patellofemoral joint.
Detailed description
Knee osteoarthritis (OA) is a common and debilitating chronic degenerative disease of the articular cartilage. Despite recent progress in the field of cartilage imaging, no routinely used clinical imaging modality has the ability to evaluate and monitor changes in cartilage degeneration. This observationnal, pilot, prospective, non randomized, uncontrolled, monocentric study aim to compare three of the most innovative imaging systems, namely the 9,4 Tesla MRI, the FFOCT (Full-Field Optical Coherence Tomography) and the ultrasound-based navigation system in order to image healthly to severely degraded human cartilage samples. All methods will be cross-correlated and compared with histological data considered as the gold standard.
Interventions
None listed
Sponsors
Clinical Investigation Centre for Innovative Technology Network
University Hospital, Grenoble
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Over 18 years of age * Knee prosthetic surgery indication with cartilage excision.
Exclusion criteria
* Subjects who refuse to sign a non-objection form
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation and comparison of histologic analysis, 9,4 Tesla MRI, FFOCT and ultrasound-based navigation system for cartilage lesions analysis of patellofemoral joint. | 6 months | Correlation between Osteoarthritis Research Society International (OARSI) grades performed for different modalities |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of FFOCT reconstructions in early osteoarthritis evaluation using visual qualitative information parameter. | 6 months | Correlation between quantitative parameters from FFOCT and gold standard OARSI grade |
| Evaluation of navigation ultrasound in early osteoarthritis evaluation using visual qualitative information parameter. | 6 months | Correlation between quantitative parameters from navigation ultrasound and gold standard OARSI grade |
| Evaluation of of 9,4 Tesla MRI reconstruction in early osteoarthritis evaluation using visual quantitative information parameter obtained for the Average Pathlength Maps. | 6 months | Correlation between quantitative parameters from the Average Pathlength Maps and gold standard OARSI grade |
| Evaluation of 9,4 Tesla MRI reconstructions in early osteoarthritis evaluation using visual qualitative information parameter obtained from the Average Pathlength Maps (APM). | 6 months | Correlation between MRI quantitative parameters and gold standard OARSI grade |
| Evaluation of navigation ultrasound in early osteoarthritis evaluation using visual quantitative information parameter. | 6 months | Thickness average of cartilage |
| Inter-observer robustness analysis of the OARSI classification | 6 months | Inter-observers Kappa coefficient |
| Intra-observer robustness analysis of the OARSI classification | 6 months | Intra-observers Kappa coefficient |
| Evaluation of FFOCT reconstructions in early osteoarthritis evaluation using visual quantitative information parameter. | 6 months | Thickness average of cartilage |
Countries
France
Outcome results
None listed