Vascular Effects of a Single Bout of Electronic Cigarette Use

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03209661

Enrollment

Registered

2017-07-06

Start date

2017-04-28

Completion date

2018-08-31

Last updated

2018-10-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arterial Stiffness

Keywords

vascular function

Brief summary

Investigating the acute effects of a single use E-Cigarette upon vascular health.

Detailed description

Subjects will inhale e-cigarettes of 5.4%, 0%, and sham menthol inhaler to determine the effects upon to measures of vascular health. These measures will include Cardio-Ankle Vascular Index and Flow Mediated Dilation.

Interventions

DRUGE-cigarette

E-Cigarette containing 5.4% nicotine will be administered to determine the effects on vascular function.

DRUGNicotine 0%

E-Cigarette containing 0% nicotine will be administered to determine the effects on vascular function.

DRUGMenthol Inhalant Product

Menthol inhaler will be administered to determine the effects on vascular function.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

OTHER

Masking

SINGLE (Subject)

Masking description

E-cigarettes being utilized are of the same brand and design. Additionally, the device will be covered by a sheath to ensure labeling is not visible to the subject.

Intervention model description

Subjects will be asked to inhale one of three mediums; 5.4% NBV e-ciggarette, 0% NBV cigarette, and sham menthol inhaler (no vapor). Baseline measurements will be conducted upon arrival and followed immediately post inhalation, 1-hour post, and finally 2-hours post. All trials will require a minimum of 48 hours washout.

Eligibility

Sex/Gender

ALL

Age

20 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* Apparently healthy, with no cardiovascular or metabolic diseases. Additionally, is not a frequent smoker of any kind.

Exclusion criteria

* Cardiovascular or Metabolic Diseases and/or regular smoker.

Design outcomes

Primary

Measure	Time frame	Description
Changes in arterial stiffness and endothelial function with e-cigarette use.	Immediately Post, 1 hour, and 2 hour.	Arterial stiffness and endothelial function are two of the subclinical markers of vascular dysfunction

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026