Immune Function
Conditions
Brief summary
A The aim of this study was to investigate the impact of consuming Weissella cibaria (W. cibaria) JW15 supplementation isolated from Kimchi, Korea traditional fermented food, on natural killer (NK) cell activity and circulating levels of cytokines and immunoglobulin (Ig).
Detailed description
A randomized, double-blinded, placebo-controlled study was conducted on 100 nondiabetic subjects. Over an eight-week testing period, the probiotic group consumed 4 capsules (300 mg/capsule) containing 1 x 10\^10 colony-forming units (cfu) of W. cibaria JW15 each day, whereas the placebo group consumed the same product without a probiotic.
Interventions
DIETARY_SUPPLEMENTPlacebo
4 capsules (300 mg/capsule) containing 52% crystalline cellulose and 46% lactose in identical-looking with test product
DIETARY_SUPPLEMENTProbiotic
4 capsules (300 mg/capsule) containing each capsule 1.0 x 10\^10 colony-forming units (cfu) of Weissella cibaria JW15, twice a day
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Nondiabetic (fasting serum glucose concentration \< 126 mg/dL) * Subjects with 4,000-8,000 leukocyte counts
Exclusion criteria
* Constant consumption of any probiotic products * Taking medicine related to inflammation within one month before screening * Allergy to probiotics * Lactose intolerance * Diabetes * History/presence of significant metabolic disease * Acute or chronic disease requiring treatment * Taking any medications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Natural killer cell activity at baseline | Baseline | Natural killer cell activity (%) |
| Natural killer cell activity at 8-week follow up | 8-week follow up | Natural killer cell activity (%) |
Outcome results
None listed