Pruritus
Conditions
Keywords
morphine, pruritus, serotonin
Brief summary
Pruritus is the commonest side effect of intrathecal morphine especially in parturient, but the exact mechanism of pruritus is not clear. Many mechanisms have been suggested. Among these mechanisms is the activation of the 5-HT3 receptors by the intrathecally injected morphine.
Detailed description
Forty parturients underwent elective cesarean section under spinal anesthesia were divided into two groups of 20 each in this prospective randomized study. Group I received 100 µg of intrathecal morphine (ITM) mixed with 12 mg of 0.5% heavy bupivacaine (M100) while group II received 200 µg of ITM mixed with 12 mg of 0.5% heavy bupivacaine (M200). Two blood samples were taken from each patient for serotonin estimation, preoperatively and 4 hrs later. Postoperatively all patients were assessed for pruritus (incidence & severity), visual analog scale (VAS), first request of analgesia, and total analgesic dose required within 24 hrs.
Interventions
DRUGMorphine 100 μg
Intrathecal injection of morphine100 μg
DRUGMorphine 200 μg
Intrathecal injection of morphine 200 μg
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* ASA I - II term pregnant patients scheduled for elective cesarean section
Exclusion criteria
* patients with a known allergy to the study drugs * significant cardiac, respiratory, renal, neurological, or hepatic disease; -coagulation disorders * BMI \> 30 kg/m2 * any itchy skin diseases.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pruritus | 24 hours postoperative | incidence |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| serotonin | preoperative | Serum level |
Outcome results
None listed