Acute Coronary Syndrome, Coronary Artery Bypass Grafting, Coronary Heart Disease, Frail Elderly Syndrome, Percutaneous Transluminal Coronary Angioplasty
Conditions
Keywords
Frailty syndrome, Coronary heart disease, Coronary revascularization, Major adverse cardiovascular events, Arterial stiffness, Applanation tonometry, Lean body mass, ST2 biomarker
Brief summary
The impact of frailty on immediate and long term outcomes of invasive treatment of coronary artery disease is not fully characterized. The assessment of frailty may help physicians in the selection of best treatment option and in the timing and modality of the follow-up. The FRAilty syndrome in daily Practice of Interventional CArdiology ward (FRAPICA) study is designed with the aim to validate the use of the Fried frailty scale and instrumental activities of daily living scale (IADL) as prognostic tools in patients admitted to hospital for symptomatic coronary artery disease, either stable, unstable, or acute coronary syndrome (ACS). The FRAPICA study is a single center prospective study enrolling patients aged ≥65 years. The aims are (1) to describe Fried frailty scale and IADL scale distribution before hospital discharge and (2) to investigate the prognostic role of Fried frailty and IADL scores. The outcomes are: (1) results of invasive treatment, (2) its complications (periinterventional MI, contrast-induced nephropathy, blood loss), (3) three-year all-cause mortality, cardiovascular mortality, stroke, myocardial infarction, reintervention, heart failure, hospital readmission for any cause, and a composite of the above mentioned. Ancillary analyses will be focused on different clinical presentations, different tools to assess frailty and risk stratification. The FRAPICA program will fill critical gaps in the understanding of the relation between frailty, cardiovascular disease, interventional procedures and outcome. It will enable more personalized risk assessment and identification of new targets for interventions.
Interventions
None listed
Sponsors
Medical University of Silesia
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* aged ≥ 65 * symptomatic coronary artery disease A) stable B) unstable C) NSTEMI D) STEMI * written, informed consent
Exclusion criteria
* lack of consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Predischarge distribution of frailty syndrome according to Fried phenotype frailty scale | Up to hospital discharge, on average day 4 | Patients will be assessed with Fried frailty scale |
| Predischarge distribution of frailty syndrome according to instrumental activities of daily living scale | Up to hospital discharge, on average day 4 | Patients will be assessed with instrumental activities of daily living scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of contrast induced nephropathy | Up to hospital discharge, on average day 4 | Number of patients with contrast induced nephropathy |
| Results of interventional treatment | Up to hospital discharge, on average day 4 | Number of patients with successful revascularization |
| Major cardiovascular events | 36 months | Number of cardiovascular deaths in long term follow-up |
| Incidence of bleeding | Up to hospital discharge, on average day 4 | Number of patients with bleeding |
| Incidence of periprocedural infarction | Up to hospital discharge, on average day 4 | Number of patients with periprocedural infarction |
Countries
Poland
Contacts
Primary ContactAndrzej R Tomasik, M.D. Ph.D., FESC
Backup ContactEwa Nowalany-Kozielska, Prof.
Outcome results
None listed