Hypovolemia, Temperature Change, Body
Conditions
Keywords
Fluid therapy
Brief summary
Fluid boluses are often administered with the aim of improving tissue perfusion in critically ill patients. It is unclear whether the temperature of the fluid has an impact on the hemodynamic response. The aim of this study is to describe the hemodynamic effects of a fluid bolus with two different temperatures.
Detailed description
A randomized, controlled, cross-over study in 21 healthy volunteers. The participants will receive a fluid bolus of 500 ml Ringer's Acetate at either 22°C or 38°C over 15 minutes in a randomized order. Non-invasive measures will be made of cardiac index, mean arterial pressure, systolic blood pressure, diastolic blood pressure, heart and pulse rate, saturation and temperature. Hemodynamic measure will be made using the Clearsight® system. Measurements will be made during 120 minutes. The second session will take place at least one day later, and the participant will then receive the other fluid temperature.
Interventions
DRUGRinger's Acetate (warm)
Body temperature fluid
DRUGRinger's Acetate (cold)
Room temperature fluid
Sponsors
Karolinska Institutet
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Masking description
Unblinded (unable to blind subjects)
Intervention model description
Crossover study of 2 different temperatures of crystalloid fluid bolus.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
\- Volunteers 18 years or older Previously healthy
Exclusion criteria
* American Society of Anesthesiologists classification 2 or above. * Known pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardiac index 15 minutes | 15 minutes | Change in cardiac index at 15 minutes from start of infusion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cardiac index 120 minutes | 120 minutes | Change in cardiac index during 120 minutes from start of infusion |
| Blood pressure 120 minutes | 120 minutes | Change in blood pressure during 120 minutes from start of infusion |
| Heart rate 120 minutes | 120 minutes | Change in heart rate during 120 minutes from start of infusion |
| Temperature 120 minutes | 120 minutes | Change in body temperature during 120 minutes from start of infusion |
Other
| Measure | Time frame | Description |
|---|---|---|
| Time to return to baseline for blood pressure | 0-120 minutes | Time to return to baseline for blood pressure |
| Time to return to baseline for heart rate | 0-120 minutes | Time to return to baseline for heart rate |
| Time to return to baseline for temperature | 0-120 minutes | Time to return to baseline for temperature |
| Time to return to baseline for CI | 0-120 minutes | Time to return to baseline for CI |
Countries
Sweden
Outcome results
None listed