Effect of Anesthetics on Microcirculation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03209193

Enrollment

Registered

2017-07-06

Start date

2017-07-04

Completion date

2019-11-07

Last updated

2020-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthetic Complication Spinal, Microcirculation

Keywords

off-pump coronary artery bypass, sevoflurane, desflurane, tissue oxygen saturation

Brief summary

Volatile anesthetics, such as sevoflurane and desflurane, are commonly used in patients undergoing cardiac surgeries including off-pump coronary artery bypass. However, the effect of volatile anesthetics on microcirculation in patients undergoing off-pump coronary artery bypass has not been well conducted.

Detailed description

This is a prospective randomized clinical trial investigating the effect of sevoflurane vs. desflurane on tissue microcirculation in patients undergoing off-pump coronary artery bypass surgery. Eligible patients are going to be randomized to receive sevoflurane or desflurane, as a maintenance anesthetic, during the surgery. Tissue oxygen saturation and microcirculatory changes, such as an occlusion and recovery slope, during vascular occlusion test will be recorded during the surgery. The primary end point of the study is the difference in tissue oxygen saturation between the groups.

Interventions

DRUGSevoflurane

Sevoflurane use as main anesthetic drug during the surgery

DRUGDesflurane

Desflurane use as main anesthetic drug during the surgery

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 90 Years

Healthy volunteers

Inclusion criteria

* scheduled for off-pump coronary artery bypass surgery

Exclusion criteria

* any deformity or vascular abnormalities on upper arms * cannot receive sevoflurane or desflurane for any reason (muscular diseases, etc) * uncontrolled diabetes * peripheral vascular disease * severe renal dysfunction (end-stage renal disease) * refuse to enroll * pregnant

Design outcomes

Primary

Measure	Time frame	Description
Tissue oxygen saturation measured at thenar eminence by Hutchinson(R) tissue oximeter during off-pump coronary artery bypass surgery	Before induction of anesthesia to the end of the surgery, an average 8 hours	Tissue oxygen saturation measured at thenar eminence by tissue oximeter during surgery in patients receiving sevoflurane or desflurane

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 26, 2026