Infertility
Conditions
Keywords
IVF, ovarian stimulation, low dose hCG, hp-FSH, Corifollitropin Alfa, costs of IVF
Brief summary
The study compares in a randomized controlled way two stimulation methods. One of these stimulation methods implements a new insight in ovarian follicular growth. If this novel method of stimulation proves to be as efficient as the classical stimulation protocols, there might be a dramatic reduction of the costs of the medical therapy in IVF, thus reducing also the overall IVf costs significantly.
Interventions
DRUGlow dose hCG
DRUGhp-FSH
DRUGCorifollitropin Alfa
Corifollitropin Alfa (Elonva) dosage depending on weight, once administered first day of ovarian stimulation for all subjects, and on day 7 they proceed with the treatment of the allocated group. \<60 kg: Elonva 100 MCG \> 60 kg: Elonva 150 MCG
Sponsors
Onze Lieve Vrouw Hospital
AZ Jan Palfijn Gent
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 38 Years
Healthy volunteers
Yes
Inclusion criteria
* IVF/ICSI patients * Cycle 1, 2, 3, 4
Exclusion criteria
* PCOS * Endocrinological diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The financial costs of the stimulation in both groups | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| The number of MII oocytes obtained at the occasion of the oocyte retrieval | 3 weeks |
| pregnancy rate | 5 weeks |
| duration of the stimulation | one month |
| hormonal levels reached at time of induction of final maturation of the oocyte | 3 weeks |
| the number of clinical OHSS patients | one month |
Countries
Belgium
Outcome results
None listed