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Relation of Implantation Site to Placental Site in Presence or Absence of Cesarean Section Scar

Relation of Implantation Site to Placental Site in Presence or Absence of Cesarean Section Scar With Doppler Assessment of Retro Chorionic Blood Flow

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03208842
Enrollment
200
Registered
2017-07-06
Start date
2017-07-15
Completion date
2018-09-30
Last updated
2017-07-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Placenta Previa

Brief summary

After gaining verbal consent , Patients included in this study will be subjected to: 1. history taking : * peronal history . * obstetric history. * past history 2. general examination including vital signs 3. abominal and pelvic examination 4. the patient will be examined son graphically at 3 visits 1. The first visit at less than 10 weeks gestation :trans vaginal ultrasound with partially filled bladder to nullify effect of anteversion of the uterus for assessment of---the site of the intrauterine gestational sac in relation to the endometrial cavity . For the purposes of this study and to obtain consistent findings, it was decided to have only five subgroups of gestational site implantation in relation to the endometrial cavity (Fig. 2): 1. anterior, 2. posterior, 3. Fundal, 4. low-lying anterior,\\ 5. low lying posterior We adopted the definition of implantation site from previous publication (Abdallah et al., 2012). The implantation site is visualized in the sagittal plane as a hyperechoic ring that occupies one side of the implanted gestational sac and protrudes into the endometrial lumen It represents the maternal decidual reaction and the beginning of maternal-fetal circulation. This area is also believed to be responsible for future placental formation and development (Brosens and Gellersen, 2010) Distance between the implantation site and the internal cervical ostium (os). This was taken from the lower end of the hyperechoic trophoblast ring of the gestational sac to the internal cervical os in the sagittal plane. * doppler assessment of the retro chorionic blood flow in the area behind the maximum chorionic tissue to detect sensitivity index (RI),in cases of low gestational sac Doppler assessment of peri trophoplastic blood flow will be assessed. 2. then the patient will be enrolled during routine ANC till delivery and data collected at32-34 weeks gestation regarding placental site will be correlated with 1st data and data at delivery

Detailed description

After gaining verbal consent , Patients included in this study will be subjected to: 1. history taking : * peronal history . * obstetric history. * past history 2. general examination including vital signs 3. abominal and pelvic examination 4. the patient will be examined son graphically at 3 visits 1. The first visit at less than 10 weeks gestation :trans vaginal ultrasound with partially filled bladder to nullify effect of anteversion of the uterus for assessment of---the site of the intrauterine gestational sac in relation to the endometrial cavity . For the purposes of this study and to obtain consistent findings, it was decided to have only five subgroups of gestational site implantation in relation to the endometrial cavity (Fig. 2): 1. anterior, 2. posterior, 3. Fundal, 4. low-lying anterior,\\ 5. low lying posterior We adopted the definition of implantation site from previous publication (Abdallah et al., 2012). The implantation site is visualized in the sagittal plane as a hyperechoic ring that occupies one side of the implanted gestational sac and protrudes into the endometrial lumen It represents the maternal decidual reaction and the beginning of maternal-fetal circulation. This area is also believed to be responsible for future placental formation and development (Brosens and Gellersen, 2010) Distance between the implantation site and the internal cervical ostium (os). This was taken from the lower end of the hyperechoic trophoblast ring of the gestational sac to the internal cervical os in the sagittal plane. -----doppler assessment of the retro chorionic blood flow in the area behind the maximum chorionic tissue to detect sensitivity index (RI),in cases of low gestational sac Doppler assessment of peri trophoplastic blood flow will be assessed. 2. then the patient will be enrolled during routine ANC till delivery and data collected at32-34 weeks gestation regarding placental site will be correlated with 1st data and data at delivery

Interventions

RADIATIONtrans vaginal ultrasound

trans vaginal ultrasound with partially filled bladder to nullify effect of anteversion of the uterus for assessment of ---the site of the intrauterine gestational sac in relation to the endometrial cavity

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No

Inclusion criteria

* singleton intrauterine pregnancy. * gestational age less than 10 weeks * history of previous cesarean section(one or more)

Exclusion criteria

* negative fetal pole pulsation. * any condition distorting uterine cavity i.e uterine myoma,uterine cavity anomalies * multifetal pregnancy. * any condition necessitate termination of early pregnancy i.e maternal medical disorder ,molar pregnancy.

Design outcomes

Primary

MeasureTime frameDescription
Placenta previaat 36 weeks of gestational agemeasuring the distance between lower placental edge and internal os of the cervix by ultrasound

Countries

Egypt

Contacts

Primary ContactAhmed Maged, MD
prof.ahmedmaged@gmail.com01005227404
Backup ContactAsmaa Ogila, MD
drasmaaibrahim@hotmail.com01001937908

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026