Multi Center Case Control Study on Multiple Risk Factors of Aplastic Anemia

Multi Center Case Control Study on Multiple Risk Factors of Aplastic Anemia Based on EDC Data Management Platform

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03208647

Acronym

MCSAA

Enrollment

1802

Registered

2017-07-05

Start date

2003-01-01

Completion date

2014-01-01

Last updated

2017-07-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aplastic Anemia

Keywords

case-control study, Multiple risk factors

Brief summary

To ascertain the risk factors of AA in ZheJiang Province of China at the moment, especially the comprehensive multiple factors risks. The author conducted a case-control research included 338 AA cases and 1464 controls. Subjects were surveyed using same standard questionnaire including personal data, past histories of diseases, family history and histories of occupational and daily exposure to harmful substances. Single and multiple Logistic regression analyses were made using SPSS17.0 on the dates to study potential factors in the development of AA.

Interventions

OTHERAA or not

to study their risk factors

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* All the patients of AA group met a AA diagnostic criteria；The control group were chosen from other departments who were under acute infection (such as pneumonia), acute abdominal emergency (such as appendicitis), cataract surgery; * 1-65 years old, male or female; * Sign the informed consent.

Exclusion criteria

* With myelodysplastic syndrome, leukaemia, multiple myeloma,megaloblastic anaemia, paroxysmal sleep hemoglobinuria disease blood disease, etc. * History of tumor, radiation or chemotherapy, once accept the immunological therapy, autoimmune diseases or allergic disease patients; * Patients with neurological diseases.

Design outcomes

Primary

Measure	Time frame	Description
the items about daily Exposures	January 2014	Whether living or working near chemical factory or ionizing radiation, whether living in newly decorated apartments/house, having pets/livestock

Secondary

Measure	Time frame	Description
Individual Behaviours	January 2014	Smoking (daily number of cigarettes )
Occupational Exposures	January 2014	the duration of exposure to harmful substance(including industrial glue）
Individual Health Status	January 2014	the time for the first onset of AA
Family disease history	January 2014	Whether having the same disease, other blood diseases, malignant tumor

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026