Endometrial Flora Characterization in Infertile Women
Conditions
Brief summary
Characterization of the female genital tract microbiome in women undergoing IVF treatment
Detailed description
The primary goal With The purpose of our study is to examine the uterine microbiome by Next-generation sequencing of the bacteria specific regions . Vaginal and uterine swabs will be taken in different women undergoing IVF /PGD. Novel bacteria and results of taxonomy assignments will be examine to find correlation of uterine flora with IVF and obstetrical outcomes. The metagenomics approach will be used to seek previously unidentified bacterial species in the human upper genital tract.
Interventions
DIAGNOSTIC_TESTEndometrial sampling of a Typical Embryo transfer catheter
no intervention no additional change from unit protocol
Sponsors
Tel-Aviv Sourasky Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 45 Years
Inclusion criteria
* All undergoning IVF treatment * Embryo transfer of one Blastocyst
Exclusion criteria
* More then one Embryo Transfer * Recent antibacterial treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To assess endometrial caracteristicas in fertile and infertile women using next generation sequencing of bacterial identification | 2017-2020 | Type of flora identified by next generation sequencing of bacterial identification |
| To identify specific endometrial flora in association to faliure of IVF treatment | 2017-2020 | Type of flora identified by NGS |
| to assess the feasibility of endometrial sampling in women undergoing embryo transfer by a standart transfer cateteher | 2017-2020 | Mode of endometrial sampling |
Outcome results
None listed