Healthy Volunteers
Conditions
Keywords
mindfulness meditation, hypnosis, meta-awareness, absorption, consciousness, self
Brief summary
Despite the increasing popularity of mindfulness meditation and hypnosis in healthcare and in the general community the underlying neurobiological mechanisms are unclear. The change in the relationship between the self and the conscious experience that they bring about may be crucial. This study aims to identify the neural correlates of self-consciousness in meta-awareness and absorption - using functional Magnetic Resonance Imaging (fMRI) in healthy participants combined with detailed first-person experiential accounts and behavioural tasks. This study will provide important clues about the widely reported effects of mindfulness meditation and hypnosis and shed light on the neural correlates of the conscious experience of self.
Interventions
BEHAVIORALcontrol, meditation, hypnosis.
three instructions will be given to each participant: control, meditation, hypnosis. The order of meditation and hypnosis will be randomized amongst two groups to avoid order effects.
Sponsors
Hospices Civils de Lyon
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* aged 18-70 * Body mass index between 18.5 and 30 * Covered by health insurance * motivated to participate * signed informed consent * normal or corrected-to-normal eyesight * sufficient command of French to be able to follow the instructions
Exclusion criteria
* history of neurological or psychiatric conditions * chronic pain or another medical condition altering pain perception * use of medication that affects the central nervous system * use of opioids or antidepressant medication * severe auditory loss * consumption of alcohol or intoxicants on the day of the experiments and the day preceding the experiments * pregnancy, breastfeeding or having given birth \<6months ago * any contra-indication to Magnetic Resonance Imaging (metal implants or foreign bodies), agitation, claustrophobia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reaction time (minutes) | at day 1 | reaction times during behavioural tasks. |
| Brain activation with IRM | At day 3 | Activation of different brain areas, as measured with functional Magnetic Resonance |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| personality trait with questionnaires | at day 2 | scores on different personality questionnaires |
| Scores during behavioural tasks | at day 1 | scores on likert scale (1-5 and 1-9) about intensity of the stimui presented during the task |
| salivary volume (millimeter) | at day 1 | salivary volume after behavioural tasks |
Countries
France
Outcome results
None listed