Prospective Study of Pain After Spinal Morphine for Cesarean Section and Factors Involved in Moderate to Severe Pain

Prospective Study of Pain After Spinal Morphine for Cesarean Section and Analysis of Factors Involved in Moderate to Severe Pain

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03205813

Enrollment

660

Registered

2017-07-02

Start date

2017-07-11

Completion date

2020-01-30

Last updated

2023-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, Postoperative

Keywords

Pain, Postoperative, Cesarean delivery, Intrathecal morphine

Brief summary

Spinal block with intrathecal morphine is a popular anesthetic technique in cesarean delivery. This technique brings about good maternal and neonatal outcomes as well as provides good postoperative pain control. Systematic review showed intrathecal morphine produced long period of pain control up to 27 hours. However, some patients still experienced moderate to severe pain which defined as postoperative pain score \>,= 4. From our institute survey, there were more than 50 percents of patients undergoing cesarean delivery receiving spinal block with intrathecal morphine experienced moderate to severe pain in the first 24 hours. The aim of the study is to determine the actual incidence and associated factors of patients whom experienced moderate to severe pain after spinal anesthesia with intrathecal morphine 200 mcg in cesarean delivery.

Detailed description

Spinal block with intrathecal morphine is a popular anesthetic technique in cesarean delivery. This technique brings about good maternal and neonatal outcomes as well as provides good postoperative pain control. Systematic review showed intrathecal morphine produced long period of pain control up to 27 hours. However, some patients still experienced moderate to severe pain which defined as postoperative pain score \>,= 4. From our institute survey, there were more than 50 percents of patients undergoing cesarean delivery receiving spinal block with intrathecal morphine experienced moderate to severe pain in the first 24 hours. Failure in achieve adequate pain control results in poor maternal satisfaction, effect breast feeding and may lead to chronic wound pain. The aim of the study is to determine the actual incidence of patients whom experienced moderate to severe pain after spinal anesthesia with intrathecal morphine 200 mcg in cesarean delivery. Also, factors that may involved moderate to severe postoperative pain will be analyzed and reported.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \> 18 years * Elective cesarean section * Patient accept spinal anesthesia * ASA classification I-II * Understand numerical rating scale for pain score

Exclusion criteria

* Not understand Thai * Contraindicated in spinal anesthesia with intrathecal morphine * Complicated pregnancy that general anesthesia may required for cesarean delivery

Design outcomes

Primary

Measure	Time frame	Description
Incidence of moderate to severe pain	The first 24 hours postoperatively	Incidence of moderate to severe pain, pain score \>,= 4

Secondary

Measure	Time frame	Description
Factors associated with moderate to severe pain	The first 24 hours postoperatively	Factors associated with moderate to severe pain, pain score \>,= 4
Incidence of moderate to severe pain in the 2nd postoperative day	Form 24 hours to 48 hours postoperatively	Incidence of moderate to severe pain (pain score \>,= 4) in the 2nd postoperative day

Countries

Thailand

Outcome results