Epidural Analgesia vs Adductor Canal Block in Bilateral TKA

Comparison Efficacy of Analgesic Techniques: Continuous Epidural Analgesia Versus Bilateral Single-shot Adductor Canal Blocks in Patients Undergoing Bilateral Total Knee Arthroplasty

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03205540

Enrollment

Registered

2017-07-02

Start date

2017-08-01

Completion date

2021-05-01

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteo Arthritis Knee

Keywords

Continuous epidural analgesia, Bilateral single-shot adductor canal blocks

Brief summary

This study evaluates postoperative analgesic efficacy within 48 hours between epidural analgesia and single-shot bilateral adductor canal blocks in bilateral total knee arthroplasty. Half of participants will be received continuous epidural analgesia, while other half of participants will be received single-shot bilateral adductor canal blocks.

Detailed description

Continuous epidural analgesia is effective postoperative pain control but it has some limitations in patients with hypotension, concurrent anticoagulants, technical difficulty, urinary retention. Adductor canal block is less invasive than continuous epidural analgesia. It provides effective analgesia for total knee arthroplasty and preserves quadriceps muscle strength.

Interventions

PROCEDUREContinuous epidural block

Continuous epidural block at level L2-3 or L3-4 with 0.0625% bupivacaine + fentanyl 2 mcg/ml infusion epidurally 5 ml/hr for 48 hours postoperatively.

PROCEDUREBilateral single-shot bilateral adductor canal blocks

Bilateral single-shot adductor canal blocks, ultrasound guidance, with 0.33% bupivacaine 15 ml on each side.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Aged more than 18 years old undergoing bilateral total knee arthroplasty * American Society of Anesthesiologists physical status classification 1-3

Exclusion criteria

* Participants deny to enroll the study * Allergy to bupivacaine * Weight less than 50 kilograms * Hepatic disease * Contraincation for neuraxial block or adductor canal block * Uncontrolled cardiovascular disease * Creatinine clearance less than 50 ml/min

Design outcomes

Primary

Measure	Time frame	Description
pain scores at rests	48 hours postoperatively	numerical rating scales

Secondary

Measure	Time frame	Description
morphine consumptions	48 hours postoperatively	total miligrams of morphine use in each arm
pain scores on movement	48 hours postoperatively	numerical rating scales
side effects of interventions	48 hours postoperatively	nausea vomiting hypotension

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026