Studying Non-motor Symptoms in HSP

Studying Non-motor Symptoms in Patients With Hereditary Spastic Paraplegia (HSP) Compared to Healthy Controls

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03204773

Enrollment

236

Registered

2017-07-02

Start date

2018-04-28

Completion date

2019-07-30

Last updated

2020-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

SPG4

Brief summary

Comparing the non-motor symptoms of patients with hereditary spastic paraplegia (HSP) to healthy controls (spouses, relatives or other healthy controls) by using the a number of specific questionaires

Detailed description

https://lamapoll.de/NMS\_in\_HSP

Interventions

DIAGNOSTIC_TESTEuroQol five dimensions questionaire (EQ-5D)

Testing quality of life.

DIAGNOSTIC_TESTModified Fatigue Impact Scale (MFI)

Screening for fatigue

DIAGNOSTIC_TESTBrief Pain Inventory (BPI)

Testing for pain

DIAGNOSTIC_TESTBecks Depression Inventory (BDI)

Screening for depression

DIAGNOSTIC_TESTRestless-leg Questionaire (RLS diagnostic criteria)

Testing for restless-legs

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Inclusion criteria

* Group 1: Patients with HSP (hereditary spastic paraplegia) * Group 2: Healthy controls * Age 18 to 70 years * Written, informed consent

Exclusion criteria

* Lack of ability for a written, informed consent * Presence of spastic gait disorder or other neurological condition (Group 2)

Design outcomes

Primary

Measure	Time frame	Description
Identification of relevant non-motor symptoms in SPG4	day 1	By using the five mentioned scales we try to identify relevant non-motor symptoms

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026