Acute Liver Injury, Bacterial Infections, Cirrhosis, Liver
Conditions
Brief summary
Acute hepatic insults including hepatitis flare-up, active alcohol assumption and hepatotoxic drug use are common in patients with cirrhosis especially in Eastern countries.These patients are at high risk of developing acute-on-chronic liver failure (ACLF) and associated with high short-term mortality. And the natural history of these patients is frequently complicated by bacterial infections, which lead to deterioration of underlying diseases. The present study is aimed to investigate the prevalance and risk factors of bacterial infections in those patients and its impact on in-hospital/short-term mortality.
Interventions
OTHERNo intervention
No intervention
Sponsors
Ningbo No.2 Hospital
The Zhejiang Study Group for Organ Failure in Cirrhosis
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
1. The presence of cirrhosis confirmed by liver biopsy, endoscopy, radiological examination, or clinical evidence of prior hepatic de-compensation; 2. Flare up of acute severe liver injury within one month before enrollment. Acute severe liver injury is defined as: increase of serum bilirubin \>=85mmol/L and international normalized ratio (INR)\>=1.5 with a definite hepatic insult.
Exclusion criteria
(1)pregnancy; (2) disseminated maliganancy; (3)previously received a liver transplant; (4) HIV infection;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Occurrence of bacterial infection | Within 3 months from admission | Site,source, pathogen and severity |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 28-day Mortality | Within 28 days after enrollment | Disease-associated mortality |
| 90-day Mortality | Within 90 days after enrollment | Disease-associated mortality |
Countries
China
Contacts
Primary ContactYu Shi, Doctor
Outcome results
None listed