Polycystic Ovary Syndrome, Glucose Intolerance, Liver Fat, Glucose Metabolism Disorders
Conditions
Brief summary
In the present study glucose metabolism and ectopic lipids in the liver, heart and muscle were investigated in women with the polycystic ovary syndrome (PCOS) and in healthy control subjects.
Detailed description
In detail an oral glucose tolerance test (OGTT) was conducted in women with the PCOS defined by the Rotterdam and the NIH-criteria, as well as in healthy control subjects. In addition 1H-magnetic resonance spectroscopy and Imaging was used for the assessment of the ectopic lipid content in the liver, heart and skeletal muscle. The aim of the present study was to compare the glucose metabolism and the ectopic lipid conent in the liver, heart and muscle between women with the PCOS defined by the NIH-criteria, Rotterdam-criteria and healthy control subjects.
Interventions
DIAGNOSTIC_TESTOral glucose tolerance test (OGTT)
For the assessment of glucose metabolism, including beta-cell function and insulin sensitivity an 75g-OGTT was conducted.
The amount of ectopic lipids in the liver, heart and the skeletal muscle was measured using 1H-magnetic resonance spectroscopy.
Sponsors
Medical University of Vienna
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Women with the polycystic ovary Syndrome defined according to the Rotterdam and the NIH-criteria * healthy control subjects
Exclusion criteria
* BMI\>=40kg/m² * Diagnosis of Diabetes in the PCOS-Group * Diagnosis of Prediabetes or Diabetes in the control group
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of glucose metabolism between PCOS women and healthy control subjects, using data of the OGTT. | Up to 4 weeks | In the present study the Glucose metabolism in PCOS women and control subjects was assessed with an OGTT. Therefore the dynamic levels of glucose, insulin and C-peptide were assessed during an extended OGTT for the calculation of Insulin resistance and beta-cell function. In addition an 1H-magnetic resonance spectroscopy was done for the assessment of the ectopic lipid content in the liver, heart and the skeletal muscle. |
Countries
Austria
Outcome results
None listed