Zika Virus, Zika Virus Infection
Conditions
Keywords
CHIKV, DENGUE, Chikungunya, DENV
Brief summary
Study to enroll up to 1000 adult patients (\>18 years) presenting with febrile or rash illness of short duration (\<72h) in designated clinics in the State of Sao Paulo, Brazil.
Detailed description
* Study to enroll up to 1000 adult patients (\>18 years) presenting with febrile or rash illness of short duration (\<72h) in designated clinics in the State of Sao Paulo, Brazil. * Following enrolment (day 0), patients will be followed up at days 2-3, 7, 14, 21, 30, 90, 180 and 360 with clinical and biological procedures (blood and urine samples). * For patients with proven ZIKA Virus (ZIKV) infection, follow-up samples will include blood, saliva, urine and genital samples. * For non-ZIKV infected patients, follow-up samples will include serological monitoring at days 14, 30, 180 and 360, and for men, possible assessment of genital fluids at day 180. * All patients will be evaluated for impact on disability up to one year. Household adult contacts of ZIKV patients will be invited for ZIKV evaluation including collection of blood and urine samples.
Interventions
None listed
Sponsors
University of Sao Paulo
University of Heidelberg Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Rash or Fever illness * within 72 hours of symptom onset
Exclusion criteria
* presence of symptoms or complications indicative of a bacterial infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ZIKA Virus Infection | up to one year | Clinical Characterization |
| DENGUE Virus Infection | up to one year | Clinical Characterization |
| Chikungunya Virus Infection | up to one year | Clinical Characterization |
Countries
Brazil
Outcome results
None listed