Sjogren's Syndrome, Vitamin D Deficiency
Conditions
Brief summary
Patients who are suspected of or diagnosed with Sjogren's disease will be evaluated for ocular symptoms and corneal nerve morphology. We are specifically interested in the relationship between Vitamin D level and aberrations in the morphology of the corneal nerves.
Detailed description
Patients with either suspected or confirmed diagnosis of Sjogren's disease will be recruited to participate. Participation will involve the completion of a brief survey (the OSDI), corneal evaluation with an aesthesiometer, corneal staining with fluorescein and lissamine green, and finally measurement of tear-film breakup time. In addition, participants will have their corneal nerve morphology evaluated with the Heidelberg confocal microscope and finally they will have a blood draw performed to assess vitamin D level.
Interventions
None listed
Sponsors
University of Pennsylvania
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Suspected or confirmed Sjogren's syndrome * 18+ years of age
Exclusion criteria
* Any condition that in the opinion of the investigator may confound study results or cause concerns for safety
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Corneal Nerve Morphology | one time exam | Heidelberg Retina Tomograph with the Rostock Cornea Module |
| Vitamin D Level | one time exam at baseline, day 1 | serum |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| vital dye staining | one time exam at baseline, day 1 | corneal staining |
Countries
United States
Outcome results
None listed