Myocellular Signalling in Skeletal Muscle

Insulin-dependent and Exercise-induced Myocellular Signalling in Skeletal Muscle

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03203317

Enrollment

Registered

2017-06-29

Start date

2017-05-01

Completion date

2017-07-26

Last updated

2017-08-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise, Insulin Sensitivity

Brief summary

The study will investigate myocellular signalling in skeletal muscle after insulin-stimulation and exercise in healthy young men

Interventions

DRUGInsulin

2 h insulin clamp

OTHERExercise

Cycling exercise

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy * informed consent * habitual training (2-5 h/week) * VO2max of 40-60 ml/min/kg * lean mass 55-65 kg

Exclusion criteria

* smoker * allergy towards insulin * chronic disease

Design outcomes

Primary

Measure	Time frame	Description
Change in muscle phospho-proteome signature	Before and after 10 minutes of exercise, as well as before and after a 2 hour insulin stimulation	proteomic analysis of mixed muscle homogenate

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026