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Comparison of Volume Controlled Ventilation With 1:1 Inspiratory to Expiratory Ratio and Autoflow-volume Controlled Ventilation in Robot-assisted Laparoscopic Radical Prostatectomy With Steep Trendelenburg Position and Pneumoperitoneum

Comparison of Volume Controlled Ventilation With 1:1 Inspiratory to Expiratory Ratio and Autoflow-volume Controlled Ventilation in Robot-assisted Laparoscopic Radical Prostatectomy With Steep Trendelenburg Position and Pneumoperitoneum

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03202953
Enrollment
78
Registered
2017-06-29
Start date
2017-07-04
Completion date
2018-01-24
Last updated
2018-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Robot Assisted Laparoscopic Prostatectomy

Brief summary

The purpose of this study is to compare the 1: 1 I: E ratio VCV and the autoflow VCV in patients undergoing robot assisted laparoscopic prostatectomy

Interventions

PROCEDUREventilation strategy 1

In Group I, after trendelenburg position, patients will be applied 1:1 ratio VCV. * Tidal volume : 8ml/kg, inspiration:expiration ratio = 1:1, FiO2 = 0.5, maintain end tidal CO2 around 40±5 mmHg. Positive end expiratory pressure will not used.

PROCEDUREventilation strategy 2

In group A, after trendelenburg position, patients will be applied autoflow VCV. \- Tidal volume : 8ml/kg, inspiration:expiration ratio = 1:2, FiO2 = 0.5, maintain end tidal CO2 around 40±5 mmHg. Positive end expiratory pressure will not used.

Sponsors

Yonsei University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)

Masking description

participants, investicator, outcome assessors will be blinded for group allocation.

Intervention model description

1. 1:1 I:E ratio VCV group 2. autoflow VCV group

Eligibility

Sex/Gender
MALE
Age
20 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

1. adult (20-80 years old) 2. patients undergoing robot assisted laparoscopic prostatectomy

Exclusion criteria

1. history of COPD 2. decreased heart function (EF \<50%) 3. BMI\>30 4. patients who cannot read the consent form (e.g., blind, foreigner)

Design outcomes

Primary

MeasureTime frameDescription
PaO230 minutes after trendelenburg positionPaO2 analyzed by arterial blood gas analysis

Secondary

MeasureTime frameDescription
PaO210 minutes after induction (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3), 10 minutes after supine position (T4)—
End tidal CO210 minutes after induction (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3), 10 minutes after supine position (T4)—
peak airway pressure10 minutes after induction (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3), 10 minutes after supine position (T4)—
blood pressure10 minutes after induction (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3), 10 minutes after supine position (T4)—
Arterial blood gas analysis10 minutes after induction (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3), 10 minutes after supine position (T4)pH, SaO2, Base excess

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026