Carotid Stenosis
Conditions
Brief summary
Diabetes is associated with an increased risk of cardiovascular complications, as a reflection of the chronic inflammatory status. Monocytes-macrophages in diabetic subjects present impaired arachidonic acid metabolism. Moreover, atheromatous plaques in diabetic subjects seem to be significantly enriched in 2-AA-LPC (2-arachidonoyl-lysophosphatidylcholine) and are more inflammatory and more likely to rupture than are plaques in non-diabetic subjects. We therefore hypothesize that this vulnerability of atheromatous plaques in diabetic subjects could be explained by impaired 2-AA-LPC metabolism within the plaque.
Interventions
PROCEDUREblood samples
3 tubes (5 ml volume) collected during surgery
PROCEDURErecover samples of atheromatous plaque
a carotid sample collected during surgery
Sponsors
Centre Hospitalier Universitaire Dijon
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who have provided explicit consent * Patients older than 18 years * Patients about to undergo surgery for carotid stenosis * Haemoglobin ≥ 7g/dl at the time the sample is taken * Respect the maximum volume of blood taken (treatment + research) in 30 days SPECIFIC TO DIABETICS \- Patients with type 1 or 2 diabetes diagnosed more than 6 months earlier
Exclusion criteria
* Patients under guardianship * Patients without health insurance cover * Pregnant or breast-feeding women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in arachidonic acid metabolism of atheromatous plaques from diabetic versus non-diabetic subjects | Baseline |
Countries
France
Outcome results
None listed