Pancreatobiliary Disease; Liver Disease
Conditions
Brief summary
Malnutrition in cancer patients continues after surgery and worsens the patient's overall health and quality of life. Previous studies reported edible insects in patients' diets increased postoperative muscle mass and weight gain. Therefore, by using nutritionally excellent mealworms for a long time, it is proved that nutritional status and survival rate are improved, leading to development of various products of edible insects.
Interventions
DIETARY_SUPPLEMENTmealworms
10g , 3 times a day , po, 2 months
DIETARY_SUPPLEMENTgrain powder
grain powder, 10g ,3times one day,2months
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
19 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Patients scheduled for surgery with pancreaticobiliary disease and liver cancer (metastatic liver cancer) * Karnofsky performance status ≥ 70 * Patients who can communicate without difficulty in obtaining a consent form for the test
Exclusion criteria
Patients with any of the following criteria are excluded. * Patients who underwent palliative surgery * Patients with uncontrolled pre-operative disease * Previous history of surgery affecting nutritional status * Pregnant and lactating women * Patients with allergy to mealworms
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improvement of Body mass index | Changes from baseline nutition index at Preoperative 1 day, Postoperative 14 days (one week after take mealworms), Postoperative 2 months( two months after take mealworms) | Improvement of Nutrition index ( Body cell mass, Soft lean mass, Fat free mass, Fat mass) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Improvement of Body weight change | Changes from baseline Body weight at Preoperative 1 day, Postoperative 14 days (one week after take mealworms), Postoperative 2 months( two months after take mealworms) | weight in kilograms, height in meters, BMI in kg/m\^2 |
| Improvement of Immune Function Index | Changes from baseline nutition index at Preoperative 1 day, Postoperative 14 days (one week after take mealworms), Postoperative 2 months( two months after take mealworms) | Improvement of Immune parameters(T cell, INF-r, TNF-a, NK cell, IL-1, IL-2) |
Countries
South Korea
Contacts
Primary ContactJoonSeong Park
Outcome results
None listed