Embryo Transfer, Fertilization in Vitro
Conditions
Keywords
frozen-thawed embryo transfer, time interval
Brief summary
Information regarding the optimal timing for frozen-thawed embryo transfer (FET) following a stimulated in vitro fertilization (IVF) is lacking. One option is to perform FET in the first cycle following the stimulated IVF cycle, i.e. immediate transfer. Another option is to postpone FET for at least one menstrual cycle, i.e. delayed transfer. This randomized study aims to compare the ongoing pregnancy rate of immediate versus delayed FET following a stimulated IVF cycle.
Interventions
OTHERimmediate frozen-thawed embryo transfer
Frozen-thawed embryo transfer will be performed in the first cycle following the stimulated IVF cycle
OTHERdelayed frozen-thawed embryo transfer
Frozen-thawed embryo transfer will be performed at least in the second cycle following the stimulated IVF cycle
Sponsors
The University of Hong Kong
ShangHai Ji Ai Genetics & IVF Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Masking description
No masking because of the nature of the intervention
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 43 Years
Healthy volunteers
No
Inclusion criteria
* Women aged ≤43 years at the time of IVF/ICSI treatment Undergoing IVF with a standard stimulation At least one frozen embryo or blastocyst The first FET cycle following ovarian stimulation in IVF/ICSI
Exclusion criteria
* Use of mild stimulation or natural cycle for IVF/ICSI treatment Severe ovarian hyperstimulation syndrome during IVF/ICSI treatment Preimplantation genetic diagnosis treatment Use of donor oocytes Presence of hydrosalpinx which is not surgically treated or endometrial polyp on scanning during ovarian stimulation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ongoing pregnancy | viable pregnancy beyond gestation 12 weeks | viable pregnancy beyond gestation 12 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Positive hCG level | A blood pregnancy test is performed 14 days after the FET | the result of serum β-hCG ≥10 mIU/mL. |
| clinical pregnancy | presence of intrauterine gestational sac on ultrasound at 6 weeks of pregnancy | presence of intrauterine gestational sac on ultrasound |
| biochemical pregnancy: | positive blood pregnancy test not followed by clinical pregnancy during 12 weeks gestation | positive blood pregnancy test not followed by clinical pregnancy |
| implantation rate | number of gestational sacs per embryo transferred during 4 weeks of pregnancy | number of gestational sacs per embryo transferred |
| multiple pregnancy | multiple pregnancy beyond gestation 12 weeks | more than one intrauterine sacs on scanning |
| miscarriage | the loss of a pregnancy before 22 weeks gestation | the loss of a pregnancy before 22 weeks gestation |
| live birth rate | a live birth after 22 weeks gestation | the rate of live births per cycle |
| birth weight | a live birth after 22 weeks gestation | birth weight of the baby delivered |
| ectopic pregnancy | ectopic pregnancy during 12 weeks gestation | pregnancy outside the uterine cavity |
Countries
China
Outcome results
None listed