Reversibility of Diastolic Disfunction in Septic Shock

Early Reversibility of Diastolic Disfunction as a Prognostic Factor in Septic Shock

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03198611

Acronym

REPRISS

Enrollment

350

Registered

2017-06-26

Start date

2018-03-01

Completion date

2019-04-01

Last updated

2018-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diastolic Dysfunction, Septic Shock

Brief summary

Objectives: To study the prognostic value of the evolution of diastolic function according to fluid balance in patients admitted to the ICU with a diagnosis of septic shock, in terms of mortality (ICU and hospital) and mortality at 90 days. 2.4. Secondary objectives: A) Incidence and reversibility of myocardial dysfunction (left ventricular systolic and diastolic) in septic shock. B) Incidence and reversibility of diastolic dysfunction according to the echocardiographic criterion used. C) Incidence and reversibility of right ventricular systolic dysfunction.

Interventions

DIAGNOSTIC_TESTEchocardiography

Usual echocardiographic studies in patients suffering septic shock

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

* Patients admitted to the ICU with diagnosis of septic shock, and stay longer than 48h

Exclusion criteria

* No echocardiographic window * Fatal prognosis with do not resuscitate orders at admission * Previous history of Ischemic cardiomyopathy * Valvular prosthesis * Advanced degree of valvular disorder * Advanced degree of pericardial effusion

Design outcomes

Primary

Measure	Time frame	Description
Mortality at 90 days	90 days	Dead at 90 days

Secondary

Measure	Time frame	Description
ICU mortality	90 days	Dead in ICU
In hospital mortality	90 days	Dead in hospital
Incidence of myocardial disfunction	During the first 24 hours of ICU admission	According to the criteria specified at groups section
Change in incidence of diastolic dysfunction	From first 24 hours of ICU admission until 48h, 72h and 7 days from admission	Change in incidence of diastolic dysfunction according to the different criteria used.

Countries

Spain

Contacts

Primary ContactLuis Zapata Fenor, MD PhD

LZapata@santpau.cat0034935537255

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026