Microbial Colonization
Conditions
Brief summary
The investigators are doing a study on the bacteria that normally live in the vagina and what effect, if any, Depo-Provera has on the bacteria. Women 13-24 years of age, who are HIV negative, being seen in a clinic for birth control or sexually transmitted disease (STD) check-up, or have a child and are planning to receive a Depo-Provera shot for contraception or have declined the use of hormonal contraception may join.
Detailed description
The investigators are doing a study on the bacteria that normally live in the vagina and what effect, if any, Depo-Provera has on the bacteria. Women 13-24 years of age, who are HIV negative, being seen in a clinic for birth control or STD check-up, or have a child and are planning to receive a Depo-Provera shot for contraception or have declined the use of hormonal contraception may join.
Interventions
OTHERNo intervention
No intervention
Sponsors
University of Maryland, College Park
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Johns Hopkins University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
13 Years to 24 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 13-24 * Female sex * Seeking contraceptive/ STI services OR has had a child OR is legally married * Has had consensual vaginal sex * Two years have passed since menses started * HIV negative by self-report * Willing to refrain from using douches, washes, or other similar feminine hygiene products. (Tampons are allowed) * Planning to receive the Depo-Provera shot, -OR- Have regular menstrual cycles with at least 21 - 45 days between menses and plans to use no hormonal birth control.
Exclusion criteria
* Any other immunodeficiency (e.g. organ transplant recipient) * Recently pregnant (within 4 weeks), currently pregnant, or planning to become pregnant within the next 12 months * Currently breastfeeding * Hysterectomy or a known genital tract anomaly * Amenorrhea (except if caused by contraceptive method like the implant) * Antibiotic or antifungal use within past 30 days
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Association between lactobacillus-dominant microbiota and sexually transmitted infections (STI) | 6 months | The investigators will determine if there is an association between lactobacillus-dominant microbiota and STIs. The investigators will report the prevalence of each vaginal community state types (CST) and STIs. |
Countries
United States
Outcome results
None listed