Effect of Short-term Oxygen During CPET in COPD

Effect of Short-term Oxygen Therapy on Cardiopulmonary Exercise (CPET) Capacity in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03196089

Enrollment

Registered

2017-06-22

Start date

2017-06-02

Completion date

2018-12-31

Last updated

2019-08-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease

Brief summary

In a randomized, sham-controlled trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with chronic obstructive pulmonary disease.

Interventions

PROCEDUREOxygen application

Supplemental oxygen via mask

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

SUPPORTIVE_CARE

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Inclusion criteria

* diagnosis of chronic obstructive pulmonary disease * on optimized medical therapy and in stable condition for at least 4 week * desaturate in the 6 minute walking test by at least 4% to values \<92%

Exclusion criteria

* unstable conditions * pregnant women * patients with relevant concomitant lung disease and severe daytime hypoxemia

Design outcomes

Primary

Measure	Time frame
Watt	1 day
Exercise time	1 day

Secondary

Measure	Time frame
Peak Oxygen uptake	1 day
Respiratory Exchange ratio	1 day
Ventilatory equivalent of carbon dioxide (VE/VCO2) slope	1 day
End-tidal pressures of carbon dioxide (PET CO2)	1 day
Changes in arterial blood parameters	1 day

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026