Pulmonary Hypertension
Conditions
Keywords
Pulmonary arterial hypertension, Chronic thromboembolic pulmonary hypertension, Hypoxia, Hyperoxia
Brief summary
Pulmonary Hypertension (PH) is a severe disease with a bad prognosis. However, thanks to extensive research in this field, there are more and better treatment options that allow patients to participate in recreational activities at moderate altitude or bring up the question of air-travel. Still very few is known about the effects hypoxic conditions have on PH patients. The aim of this study is to investigate the effects of hypoxia in comparison to normoxia and hyperoxia on pulmonary hemodynamics in patients with pulmonary hypertension during routine right heart catheterisation. We aim to get insight into the pathophysiology of pulmonary hemodynamics under hypoxic conditions in comparison to normoxia and hyperoxia in patients with pulmonary arterial and chronic thromboembolic pulmonary hypertension compared with control patients, that are scheduled for right heart catheterisation due to dyspnea but have no PH.
Interventions
OTHERHypoxia and Hyperoxia
10 minutes of breathing a gas mixture with FiO2 0.16 via a tight fitting mask. After 10 minutes of breathing ambient air (normoxia), patients were exposed to hyperoxia (FiO2 1.0) for 10 minutes.
Sponsors
University of Zurich
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* clinically indicated right heart catheterisation * diagnosis of pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension or control without pulmonary hypertension
Exclusion criteria
* hemodynamically unstable * partial pressure of Oxygen \< 7.3kPa * no informed consent * pulmonary hypertension due to left heart disease, chronic lung disease or miscellaneous (Groups II, III and V) according to Galié ERJ 2015
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of pulmonary vascular resistance during hypoxia in comparison to normoxia and hyperoxia | Day 1 |
Secondary
| Measure | Time frame |
|---|---|
| change of mean pulmonary artery pressure under hyperoxia in comparison to normoxia and hyperoxia | Day 1 |
| change of the cardiac output under hyperoxia in comparison to normoxia and hyperoxia | Day 1 |
| change of the partial pressure of carbon dioxide under hyperoxia in comparison to normoxia and hyperoxia | Day 1 |
| change of the partial pressure of oxygen under hyperoxia in comparison to normoxia and hyperoxia | Day 1 |
Countries
Switzerland
Outcome results
None listed