A Computer-based Cognitive Stimulation in Mild Cognitive Impairment With White Matter Hyperintensities

Effects of a Computer-based Cognitive Stimulation on the Verbal Learning and the Progression of White Matter Hyperintensities in Mild Cognitive Impairment: A Protocol for a Randomized Controlled Trial.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03195816

Enrollment

Registered

2017-06-22

Start date

2018-01-31

Completion date

2019-03-31

Last updated

2017-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild Cognitive Impairment

Keywords

Mild Cognitive Impairment, white matter hyperintensities, computerized cognitive training, brain plasticity

Brief summary

This is a non-pharmacological study evaluating the impact of a computerized cognitive stimulation program on verbal learning and on the progression white matter hyperintensities in elderly with mild cognitive impairment.

Detailed description

White matter hyperintensities (WMH) can appear in Mild Cognitive Impairment (MCI) and have been associated to executive, attention and processing speed deficits. Some findings indicate that the presence of WMH may contribute to Alzheimer's disease (AD) in addition to ß-amyloid, suggesting a greater vulnerability of MCI. One important challenge is to prevent or slowing down the progression of WMH. Few studies investigated the effects of computerized cognitive interventions in MCI with WMH, which deserve special attention. This study aim to investigate the effects of an intensive computer-based cognitive stimulation (CCS) program on the verbal learning in episodic memory in MCI with WMH and to explore the effects on the progression of WMH at 1-year interval.

Interventions

BEHAVIORALComputerized Cognitive training

Experimental group will receive 1 year of a computer-based cognitive stimulation program, first 6 months, 60-minutes twice a week and next 6 months once a week training in group-setting, using a tablet with a software with specific training focused on attention, executive and speed processing functions.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Outcomes Assessor)

Intervention model description

Comparison between experimental group and control group.

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of Mild Cognitive Impairment * With and without with matter hyperintensities * MRI data available or accept to perform one * No engagement in other cognitive intervention program

Exclusion criteria

* Psychiatric and neurological disorders * History of alcohol or other substance consumption * Sensory and or motor deficit that could interfere with the use of computer tool * Refusal MRI.

Design outcomes

Primary

Measure	Time frame	Description
Change on Rey Auditory Verbal Learning test	Baseline assessment in 3-weeks period before intervention, change from baseline at 6-months immediately after the end intervention, and after 3-months follow-up	Assessment of verbal learning in episodic memory

Secondary

Measure	Time frame	Description
Change on Fazekas scale	Baseline assessment of WMH severity and evolution at 12 months immediately after intervention	Assessment of white matter hyperintentisites severity on MRI

Contacts

Primary ContactAnne-Sophie AR RIGAUD, Professor

anne-sophie.rigaud@brc.aphp.fr00 33 1440835 03

Backup ContactLeila LD DJABELKHIR, Neuropsychologist

leila.djabelkhir@gmail.com00 33 6042305

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026