Cognitive Intervention in Mild Cognitive Impairment With or Without White Matter Hyperintensities

Evaluation of Differential Effects of a Computer-based-cognitive Intervention on Cognition Among Elderly With Mild Cognitive Impairment With and Without White Matter Hyperintensities: A Comparative Study.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03195803

Enrollment

Registered

2017-06-22

Start date

2015-10-31

Completion date

2017-04-30

Last updated

2017-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild Cognitive Impairment

Brief summary

This is a non-pharmacological study evaluating the differential effects of a computerized cognitive stimulation program according to the existence or not of white matter hyperintensities in elderly with mild cognitive impairment.

Detailed description

White matter hyperintensities (WMH) are increasingly recognized as a factor determining the heterogeneity of Mild Cognitive Impairment (MCI) and have been associated to executive and processing speed impairment. Cognitive interventions in MCI remain quite limited for these MCI with vascular profile and studies often distinguish patients by clinical subtypes rather than brain profile before an intervention. Considering magnetic resonance imaging (MRI) data, this study investigated the effects of a computer-based cognitive stimulation (CCS) program on MCI with WMH compared to MCI without WMH.

Interventions

BEHAVIORALComputerized Cognitive Stimulation

All participants performed 12-week, 60-minutes twice a week of a computer-based cognitive stimulation program in group-setting, using a tablet with a software with specific training focused on attention, executive and speed processing functions.

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Investigator, Outcomes Assessor)

Intervention model description

Comparison, non-randomized single blind study

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of Mild Cognitive Impairment * With and without white matter hyperintensities * MRI available or accept to perform one * No engagement in other cognitive intervention program

Exclusion criteria

* Psychiatric and neurological disorders * History of alcohol or other substance abuse * Sensory and/or motor deficit affecting the use of a tablet

Design outcomes

Primary

Measure	Time frame	Description
Rey Auditory Verbal Learning test	Baseline assessment, change from Baseline on Rey Auditory Verbal Learning test at 3 months immediately after intervention and at 3 months follow-up	Assessment of verbal learning in episodic memory

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026