Test Meal
Conditions
Keywords
Fructose, Obesity, Metabolism, Post-prandial kinetics
Brief summary
In parallel to the dramatic rise in metabolic diseases and diabetes observed over the past fifty years, the generalization of added sugar in processed food led to a marked increase in fructose consumption in almost all countries, and epidemiological studies demonstrated that the consumption of sugar-sweetened beverage (containing at least 50% of fructose) is associated with the development of diabetes, hepatic steatosis, dyslipidemia and obesity. The objective of the study is to measure the amount of fructose that escape first-pass hepatic extraction after oral ingestion (fructose+glucose), and gain insights into its metabolic fates with the use of tracers.
Interventions
OTHERTest meal
Liquid test meal (fructose+glucose)
Sponsors
University of Lausanne
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Aged from 18 to 40 years * Body Mass Index of 18.5 to 25 kg/m² * Sex male of female
Exclusion criteria
* Fructose intolerance * Antidiabetic and hypolipemic drugs * Alcohol consumption \>10g/day * Severe eating disorders * Severe psychological problems * Vegetarian diet or other specific diet * Consumption of illicit substances * Pregnancy * Weight gain or weight loss \> 3 kg in the last 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of the amount of fructose that escape first-pass hepatic extraction after oral ingestion. | The quantity of 13C fructose will be calculated, during the post prandial period, until 240 min. | Calculation with 13C fructose enrichment in blood samples at T0; 30; 60; 90; 120; 150; 180; 210 and 240 min. |
Countries
Switzerland
Outcome results
None listed