Type 2 Diabetes Mellitus
Conditions
Keywords
Type 2 diabetes mellitus, Continuous subcutaneous insulin infusion, Metformin, Linagliptin
Brief summary
Short-term intensive insulin therapy(SIIT) is able to reverse β cell dysfunction and induce glycemic remission in patients with newly diagnosed type 2 diabetes. However, proportion of patients with response gradually decreases over time. There is no consensus on which treatment should be given in order to maintain the benefit in glycemic control and β cell recovery. In this multi-center, randomized, controlled study, effects of various sequential treatments ( metformin, linagliptin and combined with both drugs) on long-term blood glucose control as well as preservation of β cell function after SIIT were investigated. In total, 412 patients with newly diagnosed type 2 diabetes who meet the inclusive criteria will be enrolled in eight centers in China. After baseline assessments, all patients will be treated with insulin pump to achieve and maintain euglycemia for 2 weeks. After completion of intensive treatment, insulin pump will be stopped. Different treatments will be applied to patients for 48 weeks according to randomization: Group A: Linagliptin 5 mg Qd + Metformin 0.5 g bid; Group B: Linagliptin 5 mg Qd; Group C: Metformin 0.5 g bid; Group D: No oral drugs. Primary endpoint is proportion of patients achieving glycosylated hemoglobin A1C \<7% at the end of the study. Secondary endpoints include proportion of patients achieving glycosylated hemoglobin A1C \<6.5% at the end of study; differences in β-cell function , insulin sensitivity, GLP-1 and glucagon secretion among treatment groups, and differences in adverse events among treatment groups.
Interventions
DRUGCSII followed by Lina+MET
short-term intensive CSII followed by Linagliptin 5mg qd and Metformin 0.5g bid for 48 weeks
DRUGCSII followed by Lina
short-term intensive CSII followed by Linagliptin 5mg qd for 48 weeks
DRUGCSII followed by MET
short-term intensive CSII followed by Metformin 0.5g bid for 48 weeks
DRUGCSII alone
No OHA is given after short-term intensive CSII
Sponsors
The Seventh Affiliated Hospital of Sun Yat-sen University
Guangdong Provincial Hospital of Traditional Chinese Medicine
Guangdong Provincial People's Hospital
The First Affiliated Hospital with Nanjing Medical University
Dongguan People's Hospital
Clifford Hospital
Guangzhou Panyu Central Hospital
Nanfang Hospital, Southern Medical University
Chinese PLA General Hospital
Peking University People's Hospital
Shanghai 10th People's Hospital
Shanghai Changzheng Hospital
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Huizhou Municipal Central Hospital
Sun Yat-sen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
1. Patients with type 2 diabetes who have never received any hypoglycemic treatment； 2. Fasting plasma glucose (FPG) between 7.0 mmol/l (126 mg/dl) and 16.7 mmol/l (300 mg/dl); 3. glycosylated hemoglobin A1C≥8.5%; 4. Aged between 20 and 70 years 5） body mass index (BMI) 22-35 kg/m2.
Exclusion criteria
1. Type 1 diabetes or special type of diabetes; 2. Acute complications of diabetes (including DKA, HHS and lactic acidosis) 3. Serious microvascular complications: proliferative stage of retinopathy; urine AER \>300 mg/g or urine protein positive, quantification \>0.5 g/d; uncontrolled painful diabetic neuropathy and significant diabetic autonomic neuropathy; 4. Severe macrovascular complications: acute cerebrovascular accident, acute coronary syndrome, vascular intervention for peripheral arterial disease or amputation requiring hospitalization within 12 months prior to enrollment; 5. Persistently increased blood pressure \>180/110 mmHg; 6. Blood creatinine clearance less than 50 ml/min, alanine aminotransferase ≥2.5×upper limit of normal, total bilirubin ≥1.5×upper limit of normal; 7. Hemoglobin \<100 g/L or need regular blood transfusion; 8. Use of drugs that may influence blood glucose within 12 weeks; 9. Systemic infection or serious concomitant disease; patients with malignancy or chronic diarrhea; 10. Uncontrolled endocrine gland dysfunction; 11. Patients with mental or communication disorders; 12. Chronic cardiac insufficiency, heart function class III and above; 13. Pregnant women, lactating women and women of child bearing age who are not willing to take contraception during the study; 14. Subjects who don't cooperate, cannot be followed up or have difficulty in completing the study considered by the investigator.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| proportion of subjects with optimal glycemic control | 48 weeks | proportion of patients achieving glycosylated hemoglobin A1C \<7% at the end of sequential treatment in each treatment group. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| proportion of subjects with excellent glycemic control | 48 weeks | proportion of patients achieving glycosylated hemoglobin A1C \<6.5% at the end of sequential treatment in each treatment group. |
| Change of β cell function | 48 weeks | Differences in β-cell indicators among treatment arms at the end of study. |
| Change of insulin sensitivity | 48 weeks | Differences in insulin sensitivity indicators among treatment arms at the end of study. |
| Incidence of adverse events | 48 weeks | Differences in incidence of adverse events among treatment arms at the end of study. |
Countries
China
Outcome results
None listed