Real-time Glaucoma Medication Adherence

Leveraging Real-Time Medication Use Monitoring to Improve Adherence in Adults With Glaucoma

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03194828

Enrollment

Registered

2017-06-21

Start date

2017-05-08

Completion date

2018-07-15

Last updated

2018-11-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma

Keywords

Adherence, Mobile health, Real-time data

Brief summary

This study will evaluate the effectiveness of real-time data collected on patients taking topical medication to treat glaucoma. Patients will be randomized to two groups, the first of which will only use the study device to take their medication, while the second will use the study device and receive on-demand reminder messages, when necessary.

Detailed description

Adherence to topical medications to treat glaucoma remains sub optimal; however, our understanding of this behavior remains limited due to biased measures of medication use. The Kali Drop device is a potential improvement in our ability to capture medication use in patients using dropper bottles by precisely capturing the amount dispensed in real-time. Moreover, such technology creates data that can be leveraged into driving behavior change using connected mobile technology in order to improve adherence and, ultimately, health outcomes. While evidence suggests that reminders may improve adherence to glaucoma medications, the power of doing so using real-time data has yet to be explored. This study will compare simple monitoring of patients to those who are being monitored and who receive reminder messages when the system determines one is necessary due to a missed dose.

Interventions

BEHAVIORALMedication reminder

Using the real-time data capture of the electronic device, an automated voice call or text message will be sent to active arm participants only when a missed dose is determined

BEHAVIORALMedication monitoring only

Patients will use an electronic medication monitoring device to record their actual medication use

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* 18 years of age and older * Glaucoma diagnosis * Prescription for a prostaglandin indicated for glaucoma * Nonadherent (MPR\<80%) in the last 3 months according to pharmacy records * Owns and operates a mobile phone and willing to receive periodic reminder messages

Exclusion criteria

* Existing chronic eye condition in addition to glaucoma * Scheduled for eye surgery in the next 90 days * Prescription for a medication that will not fit in the device * Non-English speaking

Design outcomes

Primary

Measure	Time frame	Description
Adherence	From study baseline through the 3 months of the intervention	Changes and differences in adherence to glaucoma medication between groups
Adherence follow-up	From study endpoint through the subsequent 3 months	Changes and differences in adherence to glaucoma medication between groups after the intervention

Secondary

Measure	Time frame	Description
Medication self-efficacy using the 10-item Glaucoma Medication Adherence Self-Efficacy Scale	Change from baseline over the 3-month intervention	Differences in self-reported medication-related self-efficacy between groups

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026